{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:24:14Z","timestamp":1788305054061,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Background and aims<\/jats:title><jats:p>Recent studies suggest a potential relationship between rosacea and <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) infection or small intestinal bacterial overgrowth (SIBO), but there is no firm evidence of an association between rosacea and <jats:italic>H. pylori<\/jats:italic> infection or SIBO. We performed a prospective study to assess the prevalence of <jats:italic>H. pylori<\/jats:italic> infection and\/or SIBO in patients with rosacea and evaluated the effect of <jats:italic>H. pylori<\/jats:italic> or SIBO eradication on rosacea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 90 patients with rosacea from January 2012 to January 2013 and a control group consisting of 90 patients referred to us because of mapping of nevi during the same period. We used the <jats:sup>13<\/jats:sup> C Urea Breath Test and <jats:italic>H. pylori<\/jats:italic> stool antigen (HpSA) test to assess <jats:italic>H. pylori<\/jats:italic> infection and the glucose breath test to assess SIBO. Patients infected by <jats:italic>H. pylori<\/jats:italic> were treated with clarithromycin\u2010containing sequential therapy. Patients positive for SIBO were treated with rifaximin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that 44\/90 (48.9%) patients with rosacea and 24\/90 (26.7%) control subjects were infected with <jats:italic>H. pylori<\/jats:italic> (<jats:italic>p<\/jats:italic> \u2009=\u20090.003). Moreover, 9\/90 (10%) patients with rosacea and 7\/90 (7.8%) subjects in the control group had SIBO (<jats:italic>p<\/jats:italic> \u2009=\u20090.6). Within 10 weeks from the end of antibiotic therapy, the skin lesions of rosacea disappeared or decreased markedly in 35\/36 (97.2%) patients after eradication of <jats:italic>H. pylori<\/jats:italic> and in 3\/8 (37.5%) patients who did not eradicate the infection (<jats:italic>p<\/jats:italic> \u2009&lt;\u20090.0001). Rosacea skin lesions decreased markedly in 6\/7 (85.7%) after eradication of SIBO whereas of the two patients who did not eradicate SIBO, one (50%) showed an improvement in rosacea (<jats:italic>p<\/jats:italic> \u2009=\u20090.284).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prevalence of <jats:italic>H. pylori<\/jats:italic> infection was significantly higher in patients with rosacea than control group, whereas SIBO prevalence was comparable between the two groups. Eradication of <jats:italic>H. pylori<\/jats:italic> infection led to a significant improvement of skin symptoms in rosacea patients.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640614559262","type":"journal-article","created":{"date-parts":[[2014,11,29]],"date-time":"2014-11-29T02:33:13Z","timestamp":1417228393000},"page":"17-24","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":81,"title":["<i>Helicobacter pylori<\/i> infection but not small intestinal bacterial overgrowth may play a pathogenic role in rosacea"],"prefix":"10.1002","volume":"3","author":[{"given":"AG","family":"Gravina","sequence":"first","affiliation":[{"name":"Dipartimento di Internistica Clinica e Sperimentale \u2018F Magrassi\u2019 Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Federico","sequence":"additional","affiliation":[{"name":"Dipartimento di Internistica Clinica e Sperimentale \u2018F Magrassi\u2019 Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Ruocco","sequence":"additional","affiliation":[{"name":"Department of Dermatology Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Lo Schiavo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Masarone","sequence":"additional","affiliation":[{"name":"Internal Medicine and Hepathology Department University of Salerno Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Tuccillo","sequence":"additional","affiliation":[{"name":"Dipartimento di Internistica Clinica e Sperimentale \u2018F Magrassi\u2019 Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Peccerillo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Miranda","sequence":"additional","affiliation":[{"name":"Dipartimento di Internistica Clinica e Sperimentale \u2018F Magrassi\u2019 Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Romano","sequence":"additional","affiliation":[{"name":"Dipartimento di Internistica Clinica e Sperimentale \u2018F Magrassi\u2019 Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"de Sio","sequence":"additional","affiliation":[{"name":"Dipartimento di Internistica Clinica e Sperimentale \u2018F Magrassi\u2019 Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"de Sio","sequence":"additional","affiliation":[{"name":"Dipartimento di Internistica Clinica e Sperimentale \u2018F Magrassi\u2019 Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Persico","sequence":"additional","affiliation":[{"name":"Internal Medicine and Hepathology Department University of Salerno Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Ruocco","sequence":"additional","affiliation":[{"name":"Department of Dermatology Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Riegler","sequence":"additional","affiliation":[{"name":"Dipartimento di Internistica Clinica e Sperimentale \u2018F Magrassi\u2019 Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Loguercio","sequence":"additional","affiliation":[{"name":"Dipartimento di Internistica Clinica e Sperimentale \u2018F Magrassi\u2019 Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Romano","sequence":"additional","affiliation":[{"name":"Dipartimento di Internistica Clinica e Sperimentale \u2018F Magrassi\u2019 Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(11)70077-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.03.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120625"},{"key":"e_1_2_8_5_1","first-page":"38","article-title":"Rosacea: A review","volume":"34","author":"Culp B","year":"2009","journal-title":"PT"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.04.007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.054"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1046\/j.1468-3083.2002.00497.x","article-title":"The link between Helicobacter pylori infection and rosacea","volume":"16","author":"Szlachcic A","year":"2000","journal-title":"J Eur Acad Dermatol Venerol"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12165"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70493-7"},{"key":"e_1_2_8_11_1","first-page":"501","article-title":"Effect of Helicobacter pylori eradication therapy in rosacea patients","volume":"98","author":"De Miquel DB","year":"2006","journal-title":"Rev Esp Enferm Dig"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i24.2978"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00404.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2010.02419.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12053"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.03951.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.03.043"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2012.07.006"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2002.00497.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00220.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0190-9622(00)90242-1","article-title":"Does Helicobacter pylori have a role in the pathogenesis of rosacea?","volume":"42","author":"Hirschmann JV","year":"2000","journal-title":"J Acad Dermatol"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.4.511"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.215350"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.6.659"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01144.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0634"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/35006081"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2005.02280.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00522.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-9740.2006.04646.x"},{"key":"e_1_2_8_31_1","first-page":"133","article-title":"Psoriasis and Helicobacter pylori","volume":"69","author":"Qayoom S","year":"2003","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02452.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246068"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1998.tb02440.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.117255"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2000.00028.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-34"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10227-001-0032-y"},{"key":"e_1_2_8_39_1","first-page":"2269","article-title":"Helicobacter pylori and prurigo nodularis","volume":"46","author":"Neri S","year":"1999","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000092343"},{"key":"e_1_2_8_41_1","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0190-9622(02)61465-3","article-title":"Helicobacter pylori CagA seropositivity is not strongly associated with lichen planus","volume":"49","author":"Dauden E","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_8_42_1","first-page":"576","article-title":"Helicobacter pylori infection in oral lesions of patients with recurrent aphthous stomatitis","volume":"11","author":"Mansour-Ghanaei F","year":"2005","journal-title":"Med Sci Monit"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0904-2512.2004.00074.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1089\/15230860260220175"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2003.01118.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05217.x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00172-07"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2002.01452.x"},{"key":"e_1_2_8_49_1","first-page":"30","article-title":"Diagnosis of small intestinal bacterial overgrowth in the clinical practice","volume":"2","author":"Gabrielli M","year":"2013","journal-title":"Eur Rev Med Pharmacol Sci"}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2050640614559262","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/2050640614559262","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2050640614559262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T17:25:59Z","timestamp":1693761959000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1177\/2050640614559262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1177\/2050640614559262"],"URL":"https:\/\/doi.org\/10.1177\/2050640614559262","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}