{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:55:37Z","timestamp":1791219337213,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Esophageal involvement in systemic sclerosis (SSc) carries significant morbidity and is empirically managed with domperidone, albeit with questionable efficacy. The oral 5\u2010HT<jats:sub>1A<\/jats:sub> receptor agonist buspirone may enhance esophageal peristalsis and lower esophageal sphincter (LES) function in healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to test the hypothesis that buspirone may exert a beneficial acute effect on esophageal motor dysfunction in symptomatic patients with SSc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty consecutive patients with SSc reporting esophageal symptoms underwent high\u2010resolution manometry before and 30\u2009minutes after administration of buspirone (10\u2009mg). Ten other patients received domperidone (10\u2009mg) and served as control group. Changes in LES resting and residual pressure, amplitude, duration, and velocity of distal esophageal body contractions were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Esophageal hypomotility and hypotensive LES was found in 63% and 67% of patients, respectively. Demographic and clinical characteristics, including baseline manometric parameters, were comparable between groups. Resting pressure of LES increased after buspirone from 9.42\u2009\u00b1\u20092.6 to 11.53\u2009\u00b1\u20093.4\u2009mmHg (<jats:italic>p<\/jats:italic> \u2009=\u20090.0002 by paired <jats:italic>t<\/jats:italic> \u2010test), but not after domperidone; a trend for increase of amplitude of contractions was also observed after buspirone (<jats:italic>p<\/jats:italic> \u2009=\u20090.09). Comparison of the individual changes revealed that buspirone was superior to domperidone in enhancing LES pressure (\u2009+\u20092.11\u2009\u00b1\u20092.0 versus \u20130.45\u2009\u00b1\u20092.3\u2009mmHg, <jats:italic>p<\/jats:italic> \u2009=\u20090.006). No significant effects of either drug were noted on other examined parameters of esophageal function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The beneficial acute effect of buspirone on impaired LES function associated with SSc suggests a role of 5\u2010HT<jats:sub>1A<\/jats:sub> receptor\u2010mediated interactions in these patients. Prospective studies to examine whether buspirone is of long\u2010term therapeutic value for SSc\u2010associated esophageal disease are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640614560453","type":"journal-article","created":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T03:26:44Z","timestamp":1415849204000},"page":"266-271","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Beneficial effect of the 5\u2010HT<sub>1A<\/sub> receptor agonist buspirone on esophageal dysfunction associated with systemic sclerosis: A pilot study"],"prefix":"10.1002","volume":"3","author":[{"given":"George P","family":"Karamanolis","sequence":"first","affiliation":[{"name":"Academic Department of Gastroenterology Athens Medical School \u201cLaiko\u201d GH Athens 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