{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:10:36Z","timestamp":1793200236377,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>This study aimed to test the safety and efficacy of Hemospray\u00ae for emergency control of acute variceal bleeding (AVB) due to portal hypertension in cirrhotic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>This single\u2010arm, prospective trial, conducted at two hospitals in Belgium and Egypt, included patients admitted to the emergency room with hematemesis and\/or melena and known or suspected liver cirrhosis. All patients received urgent hemodynamic stabilization, octreotide (50\u00a0mcg bolus then 25\u2009mcg\/hour for 24 hours) and intravenous ceftriaxone (1\u2009g\/hour). Endoscopy to confirm AVB and Hemospray\u00ae application (if indicated) was performed within six hours of admission. Patients were kept under observation for 24 hours and underwent second endoscopy and definitive therapy (band ligation and\/or cyanoacrylate injection in cases of gastric varices) the next day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010eight patients were admitted for suspected AVB, and 30 of these had confirmed AVB (70% male; mean age 59.5 years (range, 32.0\u201373 years)). Child\u2010Pugh class C liver disease was present in 53.4%. Esophageal varices were observed in 83.4% of patients, gastric varices in 10%, and duodenal varices in 6.6%. Spurting bleeding at the time of endoscopy was observed in 43.4%. One patient developed hematemesis six hours after Hemospray\u00ae application and underwent emergency endoscopic band ligation. No major adverse events or mortalities were observed during 15\u2010day follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hemospray\u00ae application was safe and effective at short\u2010term follow\u2010up for emergency treatment of AVB in cirrhotic patients.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640615570148","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T04:39:25Z","timestamp":1423197565000},"page":"277-283","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":55,"title":["Management of acute variceal bleeding using hemostatic powder"],"prefix":"10.1002","volume":"3","author":[{"given":"Mostafa","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hepatopancreatology and Digestive Oncology, Erasme Hospital Universit\u00e9 Libre de Bruxelles Brussels Belgium"},{"name":"Department of Gastroenterology and Hepatology Theodor Bilharz Research Institute Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"El-Mikkawy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Theodor Bilharz Research Institute Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitham","family":"Abdalla","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Theodor Bilharz Research Institute Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Theodor Bilharz Research Institute Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Devi\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatopancreatology and Digestive Oncology, Erasme Hospital Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1089-3261(05)70186-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.51"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211801"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02258.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.06.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.313"},{"key":"e_1_2_8_8_1","first-page":"115","article-title":"Cyanoacrylate glue in the management of gastric varices","volume":"100","author":"Consolo P","year":"2009","journal-title":"Minerva Med"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.432"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05903.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.12.005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1256311"},{"key":"e_1_2_8_13_1","first-page":"63","article-title":"Hemospray in the treatment of upper gastrointestinal hemorrhage in patients on antithrombotic therapy","volume":"45","author":"Holster IL","year":"2013","journal-title":"Endoscopy"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.07.024"},{"issue":"2","key":"e_1_2_8_15_1","first-page":"E86","article-title":"Use of hemostatic powder (Hemospray) in the management of refractory gastric variceal hemorrhage","volume":"45","author":"Stanley AJ","year":"2013","journal-title":"Endoscopy"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2013.07.037"},{"issue":"3","key":"e_1_2_8_17_1","first-page":"III1","article-title":"UK guidelines on the management of variceal haemorrhage in cirrhotic patients. 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