{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:22:32Z","timestamp":1777699352781,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Patients with liver cirrhosis are more prone to develop reduced bone mineral density (BMD), i.e. hepatic osteodystrophy (HOD). There are few data on the prevalence of HOD in the Indian population and its treatment. We aimed to determine the prevalence of HOD, factors associated with it and the impact of bisphosphonates on BMD in patients with liver cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Consecutive patients with liver cirrhosis admitted at Sir Ganga Ram Hospital, New Delhi, between August 2012 and July 2013 were enrolled. Patients with chronic kidney disease, hyperparathyroidism and those on steroids were excluded. BMD was measured by dual\u2010energy X\u2010ray absorptiometry (DEXA) at the lumbar spine and femoral neck. Osteopenia and osteoporosis were defined according to WHO criteria. Ibandronic acid 150\u2009mg per day orally for six months was given to patients with osteoporosis and DEXA scan repeated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 215 patients (males 179, 83%) with a mean age of 50.9\u2009\u00b1\u200911 years were enrolled in this study. Prevalence of HOD was found to be 66% (142\/215). On multivariate analysis BMI, TLC, total serum bilirubin and transient elastography values were found to be independently associated with HOD. All the patients with osteoporosis (<jats:italic>n<\/jats:italic> \u2009=\u200947) were treated with ibandronic acid as per protocol. Treated patients had significant improvement in DEXA scans after six months as compared to baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HOD was seen in two\u2010thirds of patients with liver cirrhosis. Higher liver stiffness as determined by transient elastography is significantly associated with HOD. Severity scores of liver disease (CTP and MELD) and etiology of liver cirrhosis did not determine HOD. Ibandronic acid is a safe drug that showed significant improvement in BMD in patients with liver disease along with osteoporosis.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640615584535","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T02:31:37Z","timestamp":1430879497000},"page":"77-83","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Prospective study of profile of hepatic osteodystrophy in patients with non\u2010choleastatic liver cirrhosis and impact of bisphosphonate supplementation"],"prefix":"10.1002","volume":"4","author":[{"given":"Rinkesh Kumar","family":"Bansal","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Sir Ganga Ram Hospital New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandhir","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sir Ganga Ram Hospital New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piyush Ranjan Munish","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sir Ganga Ram Hospital New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sir Ganga Ram Hospital New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.20533"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2005.07.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.3516"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1722-y"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80253-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-110-6-430"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.2.472"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840140407"},{"key":"e_1_2_7_10_1","first-page":"10","article-title":"Evaluation of hepatic osteodystrophy in patients with liver cirrhosis and correlation with severity of liver disease","volume":"8","author":"Salama AZ","year":"2007","journal-title":"Arab J Gastroenterol"},{"key":"e_1_2_7_11_1","first-page":"337","article-title":"Osteoporosis in liver cirrhosis","volume":"14","author":"Cijevevschi C","year":"2005","journal-title":"Rom J Gastroenterol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1996.tb00284.x"}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2050640615584535","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/2050640615584535","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2050640615584535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T11:09:07Z","timestamp":1693739347000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1177\/2050640615584535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1177\/2050640615584535"],"URL":"https:\/\/doi.org\/10.1177\/2050640615584535","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2]]}}}