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Patients may present with a variety of symptoms, such as dysphagia, heartburn, odynophagia, and regurgitation. Over the past years, the landscape of esophageal motility testing has been revolutionized; however, our current treatment options for IEM still remain limited. Previous studies have suggested that buspirone, a serotonin receptor agonist, enhances esophageal peristalsis and lower esophageal sphincter (LES) function. Recent work provides the first evidence that buspirone may influence LES resting pressure in patients with systemic sclerosis. Future research should evaluate whether the beneficial effects of buspirone also apply to the broad clinical entity of esophageal dysphagia patients with IEM.<\/jats:p>","DOI":"10.1177\/2050640615585688","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T00:49:58Z","timestamp":1433983798000},"page":"261-265","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Buspirone, a new drug for the management of patients with ineffective esophageal motility?"],"prefix":"10.1002","volume":"3","author":[{"given":"Charlotte","family":"Scheerens","sequence":"first","affiliation":[{"name":"KU Leuven \u2013 University of Leuven Translational Research Center for Gastrointestinal Disorders (TARGID) Department of Clinical and Experimental Medicine Leuven Belgium"},{"name":"KU Leuven \u2013 University of Leuven Research Group Experimental Otorhinolaryngology (ExpORL) Department of 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