{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:06:38Z","timestamp":1772165198717,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Endoscopic resection (ER) with or without ablation is the first choice treatment for early Barrett\u2019s neoplasia. Adequate staging is important to assure a good oncological outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The purpose of this study was to investigate the diagnostic accuracy of pre\u2010operative biopsies in patients who undergo ER for high\u2010grade dysplasia (HGD) or early adenocarcinoma (EAC) in Barrett\u2019s oesophagus (BE) and the cardia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between November 2005\u2013May 2012, 142 ERs performed in 137 patients were obtained. Worst pre\u2010ER and ER histology were compared. Upgrading\/downgrading was defined as any more\/less severe histological grading on the ER specimen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The accuracy of pre\u2010ER biopsies in predicting final histology was 61%. ER changed the pre\u2010treatment diagnosis in 55 of the 142 procedures (39%) with downgrading in 23 cases (16%) and upgrading from HGD to T1a or T1b in 32 cases (23%). In the majority of upgraded cases, a visible lesion according to the Paris classification could be detected (26\/32, 81%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The diagnostic accuracy of oesophageal biopsies alone in predicting final pathology in Barrett\u2019s dysplasia is only 61%. The majority of upgraded lesions are detectable. When ablative therapy is considered in HGD Barrett's dysplasia a meticulous inspection for and removal of all small visible lesions is mandatory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2050640615626320","type":"journal-article","created":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T22:29:00Z","timestamp":1452119340000},"page":"663-668","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Oesophageal biopsies are insufficient to predict final histology after endoscopic resection in early Barrett\u2019s neoplasia"],"prefix":"10.1002","volume":"4","author":[{"given":"E","family":"Werbrouck","sequence":"first","affiliation":[{"name":"Department of General Medical Oncology KU Leuven and University Hospitals Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"De Hertogh","sequence":"additional","affiliation":[{"name":"Department of Pathology KU Leuven and University Hospitals Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Sagaert","sequence":"additional","affiliation":[{"name":"Department of Pathology KU Leuven and University Hospitals Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Coremans","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology KU Leuven and University Hospitals Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Willekens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology KU Leuven and University Hospitals Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Demedts","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology KU Leuven and University Hospitals Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Bisschops","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology KU Leuven and University Hospitals Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji024"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0902173"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103042"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.04.010"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.04.028"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.01.031"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181fbad42"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1025-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31821d4bf6"},{"key":"e_1_2_7_11_1","unstructured":"PhoaKN PouwRE BisschopsR et al.Multimodality endoscopic eradication for neoplastic Barrett oesophagus: Results of an European multicentre study (EURO\u2010II).Gut. 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