{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T21:22:42Z","timestamp":1776201762469,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["SIBDCS: 3347CO\u2010108792"],"award-info":[{"award-number":["SIBDCS: 3347CO\u2010108792"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with ulcerative colitis may develop extraintestinal manifestations like erythema nodosum or primary sclerosing cholangitis or extraintestinal complications like anaemia, malabsorption or they may have to undergo surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate potential risk factors for complications like anaemia, malabsorption or surgery in ulcerative colitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on 179 patients with ulcerative colitis were retrieved from our cross\u2010sectional and prospective Swiss Inflammatory Bowel Disease Cohort Study data base for a median observational time of 4.2 years. Data were compared between patients with (<jats:italic>n<\/jats:italic> \u2009=\u2009140) or without (<jats:italic>n<\/jats:italic> \u2009=\u200939) complications. Gender, age at diagnosis, smoking status, disease extent, delay of diagnosis or therapy, mesalamine (5\u2010ASA) systemic and topical therapy, as well as other medication were analysed as potential impact factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the multivariate regression analysis a delay of 5\u2010ASA treatment by at least two months (odds ratio (OR) 6.21 (95% confidence interval (CI) 2.13\u201318.14), <jats:italic>p<\/jats:italic> \u2009=\u20090.001) as well as a delay with other medication with thiopurines (OR 6.48 (95% CI 2.01\u201320.91), <jats:italic>p<\/jats:italic> \u2009=\u20090.002) were associated with a higher risk for complications. This significant impact of a delay of 5\u2010ASA therapy was demonstrated for extraintestinal manifestations (EIMs) as well as extraintestinal complications (EICs). Extensive disease as well as therapy with methotrexate showed a significantly increased risk for surgery (extensive disease: OR 2.62 (1.02\u20136.73), <jats:italic>p<\/jats:italic> \u2009=\u20090.05, methotrexate: OR 5.36 (1.64\u201317.58), <jats:italic>p<\/jats:italic> \u2009=\u20090.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A delay of 5\u2010ASA therapy of more than two months in the early stage of ulcerative colitis (UC) constitutes a risk for complications during disease course. Extensive disease is associated with a higher risk for surgery.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640615627533","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T22:39:17Z","timestamp":1453243157000},"page":"281-287","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Risk factors for complications in patients with ulcerative colitis"],"prefix":"10.1002","volume":"4","author":[{"given":"Christine N","family":"Manser","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Zurich Zurich Switzerland"},{"name":"Division of Gastroenterology See\u2010Spital Horgen Horgen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Borovicka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kantonsspital St Gallen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Seibold","sequence":"additional","affiliation":[{"name":"Crohn\u2010Colitis Centre Bern\u2010Fribourg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan R","family":"Vavricka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Zurich Zurich Switzerland"},{"name":"Department of Gastroenterology and Hepatology Triemlispital Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter L","family":"Lakatos","sequence":"additional","affiliation":[{"name":"1st Department of Medicine Semmelweis University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Fried","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Zurich Zurich 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