{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:32:02Z","timestamp":1789576322904,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background and aim<\/jats:title><jats:p>Risk factors for progression of gastric atrophy have not been fully elucidated. The aim of this study was to evaluate the risk factors for the development of atrophic gastritis in patients with <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic> \u2009) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed 206 <jats:italic>H. pylori<\/jats:italic> \u2010infected patients retrospectively. Endoscopic gastric atrophy was classified into closed\u2010 and open\u2010type. We conducted univariate and multivariate logistic regression analyses on the contribution of age, sex, body mass index, past history of cancer, the first\u2010degree family history of gastric cancer, habitual smoking and alcohol drinking, and endoscopic findings of gastric ulcer or duodenal ulcer for open\u2010type gastric atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On multivariate analysis, age (odds ratio\u2009=\u20091.079, 95% confidence interval\u2009=\u20091.048\u20131.11, <jats:italic>p<\/jats:italic> \u2009&lt;\u20090.001), family history of gastric cancer (odds ratio\u2009=\u20093.967, 95% confidence interval\u2009=\u20091.414\u201310.6, <jats:italic>p<\/jats:italic> \u2009=\u20090.006) and duodenal ulcer (odds ratio\u2009=\u20090.834, 95% confidence interval\u2009=\u20090.711\u20130.977, <jats:italic>p<\/jats:italic> \u2009=\u20090.024) were the factors independently associated with open\u2010type gastric atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A first\u2010degree family history of gastric cancer, absence of duodenal ulcer, and old age were independent risk factors for the progression of gastric atrophy among <jats:italic>H. pylori<\/jats:italic> \u2010infected patients. Careful examination with upper gastrointestinal endoscopy is necessary in patients with such risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640616642341","type":"journal-article","created":{"date-parts":[[2016,3,25]],"date-time":"2016-03-25T02:17:10Z","timestamp":1458872230000},"page":"32-36","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Family history is an independent risk factor for the progression of gastric atrophy among patients with <i>Helicobacter pylori<\/i> infection"],"prefix":"10.1002","volume":"5","author":[{"given":"Toshihiro","family":"Nishizawa","sequence":"first","affiliation":[{"name":"Gastroenterology Toyoshima Endoscopy Clinic Tokyo Japan"},{"name":"Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio University School of Medicine Tokyo Japan"},{"name":"Division of Gastroenterology and Hepatology Department Of Internal Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Medical Education Center Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Sakitani","sequence":"additional","affiliation":[{"name":"Gastroenterology Toyoshima Endoscopy Clinic Tokyo Japan"},{"name":"Division of Gastroenterology The Institute for Adult Disease Asahi Life Foundation Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroharu","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Gastroenterology Toyoshima Endoscopy Clinic Tokyo Japan"},{"name":"Department of Gastrointestinal Surgery The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuntaro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Gastroenterology Toyoshima Endoscopy Clinic Tokyo Japan"},{"name":"Department of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Hata","sequence":"additional","affiliation":[{"name":"Gastroenterology Toyoshima Endoscopy Clinic Tokyo Japan"},{"name":"Department of Surgical Oncology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamitsu","family":"Kanazawa","sequence":"additional","affiliation":[{"name":"Gastroenterology Toyoshima Endoscopy Clinic Tokyo Japan"},{"name":"Department of Surgery The Fraternity Memorial Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Kanai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department Of Internal Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohisa","family":"Yahagi","sequence":"additional","affiliation":[{"name":"Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Toyoshima","sequence":"additional","affiliation":[{"name":"Gastroenterology Toyoshima Endoscopy Clinic Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"crossref","first-page":"794378","DOI":"10.1155\/2015\/794378","article-title":"Gastric Carcinogenesis and Underlying Molecular Mechanisms: Helicobacter pylori and Novel Targeted Therapy","volume":"2015","author":"Nishizawa T","year":"2015","journal-title":"Biomed Res Int"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.11-115SR"},{"issue":"2","key":"e_1_2_8_4_2","doi-asserted-by":"crossref","first-page":"S250","DOI":"10.1111\/j.1440-1746.2008.05412.x","article-title":"Expression of inducible nitric oxide synthase and nitric oxide\u2010modified proteins in Helicobacter pylori\u2010associated atrophic gastric mucosa","volume":"23","author":"Naito Y","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302084"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309252"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.158"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1098086"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.1999.09016.x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.1.22"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70410-0"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10637"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4257(01)00066-3"},{"key":"e_1_2_8_15_2","first-page":"5245","article-title":"Higher gastric cycloxygenase\u20102 expression and precancerous change in Helicobacter pylori\u2010infected relatives of gastric cancer patients","volume":"9","author":"Sheu BS","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000151297"},{"key":"e_1_2_8_17_2","doi-asserted-by":"crossref","unstructured":"The Eurohepygast Study Group. Risk factors for atrophic chronic gastritis in a European population: Results of the Eurohepygast study.Gut2002; 50: 779\u2013785.","DOI":"10.1136\/gut.50.6.779"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.15430\/JCP.2013.18.2.149"},{"key":"e_1_2_8_19_2","first-page":"2567","article-title":"Gastric mucosa alterations in first\u2010degree relatives of gastric cancer patients","volume":"25","author":"Romiti A","year":"2005","journal-title":"Anticancer Res"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-199305000-00008"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3283398d37"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2001.02380.x"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607253350404"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1109"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.01.009"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/1757-4749-2-13"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1159\/000209219"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000213241"},{"key":"e_1_2_8_29_2","first-page":"697","article-title":"Helicobacter pylori eradication restored sonic hedgehog expression in the stomach","volume":"54","author":"Nishizawa T","year":"2007","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_8_30_2","first-page":"1711","article-title":"Classification of gastritis in first\u2010degree relatives of patients with gastric cancer in a high cancer\u2010risk area in Italy","volume":"32","author":"Saieva C","year":"2012","journal-title":"Anticancer Res"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.01.003"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu7125505"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-015-0327-x"}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2050640616642341","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/2050640616642341","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2050640616642341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T12:40:27Z","timestamp":1693744827000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1177\/2050640616642341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1177\/2050640616642341"],"URL":"https:\/\/doi.org\/10.1177\/2050640616642341","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]}}}