{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:26:58Z","timestamp":1767677218371},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The <jats:italic>HLA DRB1<\/jats:italic> *08 allele associated with primary biliary cholangitis (PBC) among Caucasians is of low frequency in the Sardinian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of our study was to type a cohort of PBC patients from the island of Sardinia for HLA class II antigens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty Sardinian patients affected by PBC, 14 with autoimmune hepatitis (AIH) and 89 healthy controls (HCs) were typed for HLA class II alleles by dot\u2010blot analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PBC\u2010associated <jats:italic>HLA DRB1<\/jats:italic> *08 allele was detected in none of the studied individuals. The <jats:italic>DRB1<\/jats:italic> *0301\u2013<jats:italic>DQB1<\/jats:italic> *0201 was the prevalent HLA haplotype, detected in 19 (47.5%) out of 40\u00a0PBC haplotypes (OR\u2009=\u20093.0; 95% CI 1.5\u20136.2) and in 11 (39.3%) out of 28 AIH haplotypes (OR\u2009=\u20092.2; 95% CI 0.94\u20135.0), but in only 41 (23%) out of 178 HC haplotypes. Moreover, PBC patients showed an increased frequency of homozygosity for the <jats:italic>DQB1<\/jats:italic> *0201 allele (35% compared with 6.7% of the HCs; OR\u2009=\u20097.5; 95% CI 2.2\u201325.7). The frequency of the DRB1*11 allele in the PBC group was about half of that seen in the Sardinian HCs (7.5% vs 15.7%) (<jats:italic>p<\/jats:italic> \u2009=\u2009ns).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study confirmed the low frequency of the <jats:italic>HLA DRB1<\/jats:italic> *08 allele among Sardinians, either in the general population or PBC patients. The high prevalence of the <jats:italic>HLA DRB1<\/jats:italic> *0301\u2013<jats:italic>DQB1<\/jats:italic> *0201 haplotype is a distinctive genetic feature of PBC among Sardinians. Our study strengthens the hypothesis that still unknown genetic, epigenetic, and environmental factors must be involved in the pathogenesis of different HLA\u2010associated liver diseases, and it represents a pathfinder that warrants exploration in a future extensive study.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640616665030","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T00:18:35Z","timestamp":1470874715000},"page":"527-531","update-policy":"http:\/\/dx.doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Distinctive HLA\u2010II association with primary biliary cholangitis on the Island of Sardinia"],"prefix":"10.1002","volume":"5","author":[{"given":"Maria Grazia","family":"Clemente","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and Biotechnologies University of Cagliari Cagliari Italy"},{"name":"Present address: Department of Surgical Microsurgical and Medical Sciences University of Sassari Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulvia","family":"Frau","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Biotechnologies University of Cagliari Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilde","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"2nd Division of Medicine Azienda Ospedaliera Brotzu Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Doloretta","family":"Macis","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Biotechnologies University of Cagliari Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Cicotto","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Biotechnologies University of Cagliari Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampaolo","family":"Pilleri","sequence":"additional","affiliation":[{"name":"2nd Division of Medicine Azienda Ospedaliera Brotzu Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"De Virgiliis","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Biotechnologies University of Cagliari Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Castiglia","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Sassari Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Farci","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences \u201cMario Aresu\u201d University of Cagliari Cagliari Italy"},{"name":"Present address: Hepatic Pathogenesis Section Laboratory of Infectious Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12615"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i7.926"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-014-0460-7"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-015-8502-y"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.05.005"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03446.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.2016.1164038"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22567"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21316"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24705"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90090-8"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00189520"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2000.560605.x"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22906"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.03.005"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1955.tb01348.x"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.12.3286"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520600789859"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2002.00412.x"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9297(07)64074-9"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/0891693031000151607"},{"key":"e_1_2_8_23_2","first-page":"15","article-title":"Potential role for the plague as a selective force in Sardinia","volume":"127","author":"Sanna MV","year":"2007","journal-title":"Igiene Moderna"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.07.004"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9019"}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2050640616665030","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/2050640616665030","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2050640616665030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T12:02:08Z","timestamp":1693742528000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1177\/2050640616665030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1177\/2050640616665030"],"URL":"https:\/\/doi.org\/10.1177\/2050640616665030","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}