{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T19:06:18Z","timestamp":1773255978403,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>As the magnitude of sporadic colorectal cancer (CRC) in India is low, magnitude of CRC in ulcerative colitis (UC) is also considered low. As a result, screening for CRC in UC although advocated may not be followed everywhere. We report our data of UC\u2010related CRC from a low\u2010incidence area of sporadic CRC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1012 patients with left\u2010sided colitis\/pancolitis having more than one full\u2010length colonoscopy performed at least a year after the onset of symptoms were included in retrospective analysis of prospectively maintained case records. In addition, 136 patients with duration of disease &gt;10 years underwent surveillance white\u2010light colonoscopy prospectively during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1012\u00a0individuals were finally included (6542 person\u2010years of follow\u2010up, 68.5% males, disease duration: 6.4\u2009\u00b1\u20096.8 years). Twenty (1.97%) patients developed CRC. Two (10%) patients developed CRC during the first decade, 10\/20 (50%) during the second and 8\/20 (40%) after the second decade of disease. The cumulative risk of developing CRC was 1.5%, 7.2% and 23.6% in the first, second and third decade, respectively. Of 136 high\u2010risk UC cases, five (3.6%) had CRC on screening colonoscopy. Disease duration and increasing age of onset were associated with higher risk of CRC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cumulative risk of CRC in Indian UC patients is as high as 23.6% at 30 years. The risk of CRC increases with increasing age of onset and increasing duration of disease. A low risk of sporadic CRC does not confer a low risk of UC\u2010related CRC, and regular screening is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640616680552","type":"journal-article","created":{"date-parts":[[2016,11,19]],"date-time":"2016-11-19T01:26:23Z","timestamp":1479518783000},"page":"708-714","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Long\u2010term follow\u2010up reveals high incidence of colorectal cancer in Indian patients with inflammatory bowel disease"],"prefix":"10.1002","volume":"5","author":[{"given":"Sawan","family":"Bopanna","sequence":"first","affiliation":[{"name":"Department of Gastroenterology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saurabh","family":"Kedia","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology All India Institute of Medical Sciences New Delhi 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