{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:33:19Z","timestamp":1774528399350,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The median age of diagnosis of primary sclerosing cholangitis (PSC) is \u223c30\u201340 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to analyse disease progression and liver\u2010dependent survival in patients diagnosed with PSC after 50 years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with PSC were analysed with regard to their age at diagnosis. Patients with a first diagnosis of PSC after the age of 50 years were considered as the late\u2010onset group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 32\/215 (14.9%) patients were diagnosed with PSC after 50 years of age. The proportion of females was significantly higher among patients with late\u2010onset PSC (48.4 vs. 27.3%; <jats:italic>p<\/jats:italic> \u2009=\u20090.02). Patients with later diagnosis required dilatation therapy more often due to dominant stenosis (84.2 vs. 53.1%; <jats:italic>p<\/jats:italic> \u2009=\u20090.01) and suffered from recurrent cholangitis more often (48.3 vs. 21.0%; <jats:italic>p<\/jats:italic> \u2009=\u20090.003). Patients with late\u2010onset PSC had reduced transplantation\u2010free survival (10.5\u2009\u00b1\u20090.6 years vs. 20.8\u2009\u00b1\u20091.7 years, <jats:italic>p<\/jats:italic> \u2009&lt;\u20090.0001), with progredient liver failure and cholangiocarcinoma as the leading causes of death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with later age at diagnosis of PSC displayed a different clinical phenotype with a different sex ratio, immune status and an increased risk for progressive liver failure and biliary malignancies.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640617717156","type":"journal-article","created":{"date-parts":[[2017,6,17]],"date-time":"2017-06-17T07:42:23Z","timestamp":1497685343000},"page":"255-262","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Impact of age at diagnosis on disease progression in patients with primary sclerosing cholangitis"],"prefix":"10.1002","volume":"6","author":[{"given":"Christian","family":"Rupp","sequence":"first","affiliation":[{"name":"Department of Internal Medicine IV University Hospital of Heidelberg Heidelberg Germany"},{"name":"Interdisciplinary Endoscopy Unit University Hospital of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"R\u00f6ssler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV University Hospital of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taotao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV University Hospital of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conrad","family":"Rauber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV University Hospital of Heidelberg Heidelberg 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