{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:27:49Z","timestamp":1773746869235,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100013668","name":"Cancer Focus Northern Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Background<\/jats:title>A systematic review suggests that 25% of oesophageal adenocarcinomas (OAC) are \u2018missed\u2019 at index endoscopy for Barrett's oesophagus (BO); however, this included few population\u2010based studies and may be an overestimate.<\/jats:p><\/jats:sec>Objective<\/jats:title>The objective of this article is to quantify the \u2018missed\u2019 rates of high\u2010grade dysplasia (HGD) and OAC at index BO endoscopy.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients from the Northern Ireland BO register diagnosed between 1993 and 2010 (n<\/jats:italic>\u2009=\u200913,159) were linked to the Northern Ireland Cancer Registry to identify patients who developed OAC or HGD. Logistic regression analysis compared characteristics of \u2018missed\u2019 vs \u2018incident\u2019 HGD\/OAC, defined as diagnoses within 3\u201312 months vs >1 year after incident BO, respectively.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 267 patients were diagnosed with HGD\/OAC \u22653 months after BO diagnosis, of whom 34 (12.7%) were potentially \u2018missed\u2019. The proportion of \u2018missed\u2019 HGD\/OAC was 25% among BO patients with low\u2010grade dysplasia (LGD) and 9% among non\u2010dysplastic BO patients. Older age and BO\u2010LGD carried a higher risk of \u2018missed\u2019 HGD\/OAC. Non\u2010dysplastic BO patients were more often diagnosed with a \u2018missed\u2019 OAC (rather than HGD; 89%), compared with BO\u2010LGD patients (40%).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Approximately one in 10 HGD\/OAC cases are \u2018missed\u2019 at incident BO diagnosis, which is significant but lower than previous reports. However, \u2018missed\u2019 HGD\/OAC cases represent only 0.26% of all BO patients.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640617737466","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T04:48:51Z","timestamp":1507783731000},"page":"519-528","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["\u2018Missed\u2019 oesophageal adenocarcinoma and high\u2010grade dysplasia in Barrett's oesophagus patients: A large population\u2010based study"],"prefix":"10.1002","volume":"6","author":[{"given":"Margreet","family":"van Putten","sequence":"first","affiliation":[{"name":"Department of Research Netherlands Comprehensive Cancer Organisation (IKNL) Eindhoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian T","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Royal Victoria Hospital Belfast 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