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Most gastric cancers develop in a stepwise progression from chronic active gastritis to precursor lesions of gastric cancer. The early detection of gastric cancer improves survival. Studies with recent evidence have proposed circulating\u2010microRNAs as biomarkers of cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to explore the circulating\u2010microRNA profile from <jats:italic>H. pylori<\/jats:italic> infection to gastric adenocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and twenty\u2010three patients were enrolled and assigned to the discovery or the validation sets. In the discovery phase, circulating\u2010microRNAs were measured by dye\u2010based quantitative polymerase chain reaction and a selection of circulating\u2010microRNAs was validated by probe\u2010based quantitative polymerase chain reaction. A quality control protocol was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and sixty\u2010seven circulating\u2010microRNAs were detected. Precursor lesions of gastric cancer and gastric cancer patients showed the downregulation of eight and five circulating\u2010microRNAs, respectively. We further validated the deregulation of miR\u2010196a\u20105p in precursor lesions of gastric cancer and the deregulation of miR\u2010134\u20105p, miR\u2010144\u20103p and miR\u2010451a in gastric cancer. However, circulating\u2010microRNAs exhibited moderate diagnostic performance due to the overlap of circulating\u2010microRNA expression between non\u2010cancer and cancer patients. miR\u2010144\u20103p\/miR\u2010451a expression levels were correlated. Interestingly, these microRNAs are in 17q11.2, a site of rearrangements associated with gastric cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Circulating\u2010microRNAs are deregulated in precancerous and gastric cancer patients but efforts are needed to improve their diagnostic accuracy.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640618759433","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T09:28:05Z","timestamp":1519810085000},"page":"691-701","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Expression profile of circulating microRNAs in the Correa pathway of progression to gastric cancer"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9294-1585","authenticated-orcid":false,"given":"Sergio","family":"Lario","sequence":"first","affiliation":[{"name":"Fundaci\u00f3 Parc Taul\u00ed 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