{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:30:14Z","timestamp":1778643014405,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Background<\/jats:title>An on\u2010site, rapid, fingertip, whole\u2010blood point\u2010of\u2010care test (POCT) is attractive for active case\u2010finding of coeliac disease (CD) in primary care because of its simplicity.<\/jats:p><\/jats:sec>Aim<\/jats:title>The aim of this article is to assess the usefulness and cost\u2010effectiveness of adult case\u2010finding using a POCT based on deamidated gliadin peptide antibodies (IgA\/IgG\u2010DGP) in primary care for CD diagnosis.<\/jats:p><\/jats:sec>Methods<\/jats:title>A case\u2010finding study for CD was conducted by using an easy\u2010to\u2010use, on\u2010site, whole\u2010blood for IgA\/IgG\u2010DGP\u2010based fingertip POCT compared with tTG2 in 350 individuals. Sample size was calculated based on 0.28% prevalence in the reference population. Duodenal biopsies for histology, intraepithelial lymphocytes and in situ deposition of tTG2 were obtained if tTG2 and\/or POCT were positive. Accuracy and cost\u2010effectiveness of strategies using serology or POCT were calculated.<\/jats:p><\/jats:sec>Results<\/jats:title>Prevalence of CD was 1.14% (95% CI, 0.3\u20133.4), almost double what was previously observed. Four patients were diagnosed with CD. tTG2 was positive in three (0.85%) and POCT in 29 (8.2%). Sensitivity of POCT for CD was 100%, specificity 93%, PPV 14%, and NPV 100%. POCT followed by duodenal biopsy was the most cost\u2010effective approach in our setting (standard diagnosis: \u20ac13,033\/case; POCT\u2009+\u2009duodenal biopsy: \u20ac7360\/case).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>A negative POCT allows ruling out CD in primary care, making it suitable for case\u2010finding. POCT strategy was the most cost effective.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640618761700","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T16:35:57Z","timestamp":1519144557000},"page":"855-865","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Case\u2010finding in primary care for coeliac disease: Accuracy and cost\u2010effectiveness of a rapid point\u2010of\u2010care test"],"prefix":"10.1002","volume":"6","author":[{"given":"Maria","family":"Esteve","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hospital Universitari Mutua Terrassa Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de enfermedades hep\u00e1ticas y digestivas (CIBEREHD) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merc\u00e8","family":"Rosinach","sequence":"additional","affiliation":[{"name":"Department of 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