{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:07:52Z","timestamp":1787612872957,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["7-11-0213"],"award-info":[{"award-number":["7-11-0213"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011033","name":"Thermo Fisher Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011033","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dansk C\u00f8liaki Forening"},{"DOI":"10.13039\/501100007437","name":"Tryg Foundation","doi-asserted-by":"crossref","award":["7-11-0213"],"award-info":[{"award-number":["7-11-0213"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Human leukocyte antigen (HLA) DQ2 and DQ8 are important risk factors for some autoimmune diseases such as celiac disease (CD), but their possible role in other diseases and health conditions is not fully explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this article is to examine the distribution of HLA DQ2 and HLA DQ8 in an adult general population, and their association with health indicators (diseases, symptoms and biomarkers).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional, population\u2010based study, 2293 individuals were screened for HLA DQ2 and DQ8; CD\u2010associated alleles (DQA*0201*03*05\/DQB*02*0301\/0304*0302\/0305) and DQB1*02 homozygosity were determined for screen\u2010positive participants. The National Patient Registry provided diagnosis information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 47.7% (1093\/2293) individuals were positive for DQ2 and\/or DQ8: 31.2% (716\/2293) only DQ2, 11.9% (273\/2293) only DQ8, 4.1% (93\/2293) both DQ2 and DQ8. Among nine individuals diagnosed with CD, 89.9% (8\/9) had DQ2.5<jats:italic>cis<\/jats:italic>, 22.2% (2\/9) DQ8 and 22.2% (2\/9) DQ2.2 (two both DQ2 and DQ8). HLA DQ2.5 was associated with higher thyroid\u2010stimulating hormone levels, while DQ2\/DQ8\u2010positive participants had significantly lower prevalence of irritable bowel syndrome (IBS). DQ2\/DQ8 were strongly associated with CD, but no other registry\u2010based diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this general Danish population, 47.7% were HLA DQ2\/DQ8 positive and thus potentially at risk for CD. All individuals with CD were DQ2\/DQ8 positive; the majority DQ2.5. Surprisingly, DQ2\/DQ8\u2010positivity was associated with lower IBS prevalence.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640618765506","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T14:30:15Z","timestamp":1520519415000},"page":"866-878","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["The distribution of HLA DQ2 and DQ8 haplotypes and their association with health indicators in a general Danish population"],"prefix":"10.1002","volume":"6","author":[{"given":"Line Lund","family":"K\u00e5rhus","sequence":"first","affiliation":[{"name":"Center for Clinical Research and Prevention Bispebjerg and Frederiksberg Hospital Capital Region Copenhagen Denmark"},{"name":"Research Centre for Prevention and Health The Capital Region Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betina H","family":"Thuesen","sequence":"additional","affiliation":[{"name":"Center for Clinical Research and Prevention Bispebjerg and Frederiksberg Hospital Capital Region Copenhagen Denmark"},{"name":"Research Centre for Prevention and Health The Capital Region Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tea","family":"Skaaby","sequence":"additional","affiliation":[{"name":"Center for Clinical Research and Prevention Bispebjerg and Frederiksberg Hospital Capital Region Copenhagen Denmark"},{"name":"Research Centre for Prevention and Health The Capital Region Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcri J","family":"Rumessen","sequence":"additional","affiliation":[{"name":"Q&amp;D-Research Unit and Department of Gastroenterology Herlev and Gentofte Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Linneberg","sequence":"additional","affiliation":[{"name":"Center for Clinical Research and Prevention Bispebjerg and Frederiksberg Hospital Capital Region Copenhagen Denmark"},{"name":"Research Centre for Prevention and Health The Capital Region Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Department of Clinical Experimental Research Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h4347"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-017-0985-7"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000369512"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-012-0599-z"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.11.021"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.320374"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400697"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-013-0352-1"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000369535"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01182.x"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2011.11.003"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1981.tb01391.x"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1981.tb01390.x"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1010571"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt009"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000709"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12704"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609006767"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1117652"},{"key":"e_1_2_11_22_2","first-page":"33","article-title":"Data validity and coverage in the Danish National Health Registry. 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