{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:07:07Z","timestamp":1789596427972,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The use of interferon\u2010free direct\u2010acting antiviral agents (DAAs) is associated with a rapid short\u2010term decrease in liver stiffness in chronic hepatitis C\u2010infected patients with sustained virologic response (SVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this article is to evaluate long\u2010term changes in liver elasticity in hepatitis C patients with SVR using transient elastography (TE), FIB\u20104 and APRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 143 patients were treated with DAAs and reached SVR. Patients received TE measurement (median (range)) at treatment start (baseline), follow\u2010up week 24 (FU24) and follow\u2010up week 96 (FU96). Laboratory data were examined at each date and FIB\u20104 and APRI were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Liver elasticity showed a significant decrease from baseline to FU24 (13.1 (3.1\u201375) kPa to 9.3 (2.9\u201369.1) kPa; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and declined further until FU96 (7.9 (2.4\u201359.3) kPa; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Liver inflammation and liver function parameters normalised during long\u2010term follow\u2010up. Progression of liver stiffness between FU24 to FU96 despite viral clearance was observed in 24 patients (17%). Long\u2010term liver stiffness progression was associated with aspartate aminotransferase levels and TE change from baseline to FU24.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>During long\u2010term follow\u2010up, the majority of patients with SVR had further improved liver stiffness values. Still, a significant proportion of patients may show long\u2010term liver stiffness progression and thus continued TE follow\u2010up is recommended.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640618786067","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T06:37:16Z","timestamp":1530167836000},"page":"1188-1198","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Long\u2010term changes in liver elasticity in hepatitis C virus\u2010infected patients with sustained virologic response after treatment with direct\u2010acting antivirals"],"prefix":"10.1002","volume":"6","author":[{"given":"Veronika","family":"Pietsch","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology Hannover Medical School Hannover 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