{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T22:26:27Z","timestamp":1749853587621,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The diagnostic yield of the faecal immunochemical test and sigmoidoscopy in detecting proximal serrated polyps in a colorectal cancer screening programme has not been fully assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We determined the detection rate of proximal serrated polyps by simulated sigmoidoscopy and faecal immunochemical test compared with total colonoscopy in a population\u2010based, multicentre, nationwide, randomised controlled trial (ColonPrev study).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sigmoidoscopy yield was simulated based on the UK\u2010Flexible Sigmoidoscopy Trial for total colonoscopy referral. Definitions were: proximal serrated polyp (proximal serrated polyp): sessile serrated polyp or hyperplastic polyp of any size and proximal at\u2010risk serrated polyp (at\u2010risk proximal serrated polyp): sessile serrated polyp of any size or hyperplastic polyp\u2009\u2265\u200910\u2009mm, both located proximally to the splenic flexure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 10,611 individuals underwent faecal immunochemical test and 5059 underwent total colonoscopy and were evaluated by simulated sigmoidoscopy. Sigmoidoscopy and faecal immunochemical test were less accurate in detecting proximal serrated polyps (odds ratio: 0.13; 95% confidence interval: 0.10\u20130.18 and 0.13; 0.09\u20130.18, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001, respectively). Both tests were inferior to colonoscopy in detecting at\u2010risk proximal serrated polyps, and sigmoidoscopy was inferior to faecal immunochemical test in detecting these lesions (odds ratio: 0.17; 95% confidence interval: 0.10\u20130.30 and 0.25; 0.17\u20130.37, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sigmoidoscopy and faecal immunochemical test are less accurate in detecting proximal serrated polyps than colonoscopy, particularly in women.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640618804722","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T07:26:50Z","timestamp":1537946810000},"page":"1527-1537","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Detection of serrated lesions in proximal colon by simulated sigmoidoscopy vs faecal immunochemical testing in a multicentre, pragmatic, randomised controlled trial"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6507-9571","authenticated-orcid":false,"given":"Laura","family":"Carot","sequence":"first","affiliation":[{"name":"Gastroenterology Department Hospital del Mar Barcelona Spain"},{"name":"Hospital del Mar Medical Research Institute (IMIM) Barcelona Spain"},{"name":"Autonomous University of Barcelona Medicine Department Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Castells","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital Cl\u00ednic de Barcelona Universitat de Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Epidemiology and Evaluation Department Hospital del Mar Barcelona 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