{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:53:38Z","timestamp":1791978818081,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Missed oesophageal cancer (MEC) at upper gastrointestinal endoscopy (UGE) is poorly documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objectives of this study were: (1) to assess the rate, predictors and survival of MEC; (2) to compare MEC and non\u2010MEC tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study conducted at four tertiary centres. Oesophageal cancers (ECs) diagnosed between 2008 and 2015 were included. Patients with a premalignant condition (Barrett, achalasia), prior diagnosis of EC or oesophagogastric junction tumour of gastric origin were excluded. MEC was defined as EC detected within 36 months after negative UGE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>123,395 UGEs were performed during the study period, with 502 ECs being diagnosed (0.4%). A total of 391 ECs were finally included. Overall MEC rate was 6.4% (95% confidence intervals (CI): 4.4\u20139.3%). The interval between negative and diagnostic UGE was less than 2 years in 84% of the cases. Multivariate analysis showed that a negative endoscopy was associated with proton pump inhibitor (PPI) therapy and less experienced endoscopists. MEC was smaller than non\u2010MEC at diagnosis (25 versus 40\u2009mm, <jats:italic>p<\/jats:italic>\u2009=\u20090.021), more often flat or depressed (<jats:italic>p<\/jats:italic>\u2009=\u20090.013) and less frequently diagnosed as metastatic disease (<jats:italic>p<\/jats:italic>\u2009=\u20090.013). Overall 2\u2010year survival rate was similar for MEC (20%) and non\u2010MEC (24.1%) (<jats:italic>p<\/jats:italic>\u2009=\u20090.95).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MEC accounted for 6.4% of all ECs and was associated with poor survival. High\u2010quality UGE and awareness of MEC may help to reduce its incidence.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640618811477","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T18:15:39Z","timestamp":1541009739000},"page":"189-198","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":78,"title":["Rate of missed oesophageal cancer at routine endoscopy and survival outcomes: A multicentric cohort study"],"prefix":"10.1002","volume":"7","author":[{"given":"Enrique","family":"Rodr\u00edguez de Santiago","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hospital Universitario Ram\u00f3n y Cajal University of Alcala Madrid Spain"},{"name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Biosanitaria (IRYCIS) Madrid 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