{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:52:08Z","timestamp":1785873128532,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Finansed by Polish Ministry of Science & Higher Education, Polish Mother's Memorial Hospital \u2013 Research Institute","award":["Young Researcher Internal Grant [No 2015\/IV\/49-MN]"],"award-info":[{"award-number":["Young Researcher Internal Grant [No 2015\/IV\/49-MN]"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Primary lactose intolerance (PLI) is a gradual decrease of lactase activity that usually manifests at the age of 1\u20135 years. It has been proved that PLI is related to a single\u2010nucleotide polymorphism of the lactase (<jats:italic>LCT<\/jats:italic>) gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>An evaluation was performed on the usefulness of genetic tests in detecting <jats:italic>LCT<\/jats:italic> 13910C&gt;T and 22018G&gt;A polymorphisms in diagnosing lactose intolerance in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study group included 99 children aged from 2 months to 16.5 years with different digestive tract symptoms. In all patients a hydrogen breath test (HBT) was conducted and blood samples were collected to determine <jats:italic>LCT<\/jats:italic> polymorphisms. PLI was defined as the presence of the 13910CC and\/or 22018GG polymorphism in patients with a positive HBT result.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the group younger than 6 years, no statistically significant correlation was observed between the 13910CC and\/or 22018GG LCT polymorphisms and HBT result. In the group of children older than 6, a statistically significant correlation between the 13910CC (<jats:italic>p<\/jats:italic>\u2009=\u20090.0011) and 22018GG (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) <jats:italic>LCT<\/jats:italic> polymorphisms and HBT result was detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In children older than 6, the result of genetic testing based on <jats:italic>LCT<\/jats:italic> 13910C&gt;T and 22018G&gt;A polymorphisms may diagnose lactose intolerance.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640618814136","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T02:55:16Z","timestamp":1542336916000},"page":"210-216","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["13910C&gt;T and 22018G&gt;A <i>LCT<\/i> gene polymorphisms in diagnosing hypolactasia in children"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1426-4640","authenticated-orcid":false,"given":"J","family":"Tomczonek-Moru\u015b","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Immunology and Nephrology Polish Mother's Memorial Hospital Research Institute \u0141\u00f3d\u017a Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Wojtasik","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Immunology and Nephrology Polish Mother's Memorial Hospital Research Institute \u0141\u00f3d\u017a Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Zeman","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Immunology and Nephrology Polish Mother's Memorial Hospital Research Institute \u0141\u00f3d\u017a 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