{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:29:45Z","timestamp":1793089785573,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although acute kidney injury (AKI) often accompanies acute liver failure (ALF), its impact on long\u2010term outcome is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study examines the incidence, severity and outcomes of AKI in patients with ALF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 134 ALF patients treated at Hannover Medical School between 1995 and 2013 were retrospectively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010four ALF patients (40.3%) demonstrated AKI, as defined by the acute kidney injury network (AKIN) classification, on intensive care unit (ICU) admission, and 85 patients (63.4%) developed AKI prior to ALF recovery, emergency liver transplantation (ELT) or death. AKI severity was closely associated with other end\u2010organ damage (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Follow\u2010up creatinine levels in survivors were increased compared to baseline levels (76 versus 64\u2009\u00b5mol\/l,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). One\u2010hundred\u2010and\u2010three (76.9%) patients reached the combined endpoint of ELT or death, and 42 (31.3%) patients died within 28 days. AKIN stage 3 at ICU admission was the strongest independent predictor of 28\u2010day overall mortality (hazard ratio 3.48, 95% confidence interval 1.75\u20136.93,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and ELT or death (hazard ratio 2.52, 95% confidence interval 1.60\u20133.96,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AKI is a frequent complication in ALF that correlates with remote organ damage and long\u2010term creatinine levels and independently predicts outcome.<\/jats:p>\n                  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Klinikum Braunschweig Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Manns","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Endocrinology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"K\u00fcmpers","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Nephrology, and Rheumatology Department of Medicine D University Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Lukasz","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Nephrology, and Rheumatology Department of Medicine D University Hospital M\u00fcnster M\u00fcnster 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