{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:57:19Z","timestamp":1776128239785,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The effect of current infection of <jats:italic>Helicobacter pylori<\/jats:italic> on gastric cancer has rarely been studied in a large population. We investigated the association of current <jats:italic>H. pylori<\/jats:italic> infection and metabolic factors with gastric cancer in a large population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Persons who made their first visit to the National Cancer Center for a health examination, including endoscopy and <jats:italic>H. pylori<\/jats:italic> testing using gastric tissue between 2003 and 2013, were included. The association of <jats:italic>H. pylori<\/jats:italic> with gastric cancer was estimated using odds ratios (ORs) and 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 35,519 people, 113 gastric cancer and 158 gastric dysplasia cases were detected. In the adjusted analysis, gastric cancer was associated with current <jats:italic>H. pylori<\/jats:italic> infection (OR, 2.39; 95% CI, 1.53\u20133.74), age (OR, 1.06; 95% CI 1.04\u20131.08), first\u2010degree relatives with gastric cancer (OR, 2.08; 95% CI, 1.30\u20133.32) and hyperglycaemia (OR, 1.66; 95% CI, 1.04\u20132.65), whereas it was inversely associated with high\u2010density lipoprotein (HDL) (OR, 0.49; 95% CI, 0.22\u20130.94). In the subanalysis, gastric cancer was associated with first\u2010degree relatives with gastric cancer (OR, 3.23; 95% CI, 1.39\u20137.50) in the absence of <jats:italic>H. pylori<\/jats:italic>, whereas it was associated with hyperglycaemia (OR, 1.98; 95% CI, 1.16\u20133.39) in the presence of <jats:italic>H. pylori.<\/jats:italic><\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gastric cancer was associated with current <jats:italic>H. pylori<\/jats:italic> infection, hyperglycaemia, and low HDL levels in a large population.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640618819402","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T13:07:02Z","timestamp":1544620022000},"page":"287-296","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Association of current <i>Helicobacter pylori<\/i> infection and metabolic factors with gastric cancer in 35,519 subjects: A cross\u2010sectional study"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5568-7714","authenticated-orcid":false,"given":"Su","family":"Youn Nam","sequence":"first","affiliation":[{"name":"Gastroenterology Center for Gastric Cancer<!--<institution-id institution-id-type=\"Ringgold\">65396<\/institution-id>--> Kyungpook National University Hospital Daegu Korea"},{"name":"Department of Internal Medicine Center for Cancer Prevention and Detection Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bum Joon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Center for Cancer Prevention and Detection Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7083-7581","authenticated-orcid":false,"given":"Ji Hyung","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Center for Cancer Prevention and Detection Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kum Hei","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Center for Cancer Prevention and Detection Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myeong-Cherl","family":"Kook","sequence":"additional","affiliation":[{"name":"Department of Pathology Center for Gastric Cancer Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeongseon","family":"Kim","sequence":"additional","affiliation":[{"name":"Molecular Epidemiology Branch<!--<institution-id institution-id-type=\"Ringgold\">70317<\/institution-id>--> National Cancer Center Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Kee","family":"Lee","sequence":"additional","affiliation":[{"name":"Biostatistics<!--<institution-id institution-id-type=\"Ringgold\">65396<\/institution-id>--> Kyungpook National University Hospital and School of Medicine Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3]]},"reference":[{"key":"e_1_2_12_2_2","first-page":"1","article-title":"Schistosomes, liver flukes and Helicobacter pylori. 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