{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T14:21:23Z","timestamp":1794406883219,"version":"4.9.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2019,4]]},"abstract":"\n Introduction<\/jats:title>\n Only a minority of patients with a positive fecal occult blood test (FOBT) undergo a follow\u2010up second diagnostic procedure, thus minimizing its contribution for colorectal cancer (CRC) prevention. We aimed to obtain a precise estimation of this problem and also assess the diagnostic yield of CRC and adenomas by colonoscopy in these patients.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Literature searches were conducted for \u201ccompliance\u201d OR \u201cadherence\u201d AND \u201cfecal occult blood test\u201d OR \u201cfecal immunohistochemical test\u201d AND \u201ccolonoscopy.\u201d Comprehensive meta\u2010analysis software was used.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The search resulted in 42 studies (512,496 patients with positive FOBT), published through December 31, 2017. A funnel plot demonstrates a moderate publication bias. Compliance with any second procedure, colonoscopy, or combination of double\u2010contrast barium enema with or without sigmoidoscopy in patients with a positive FOBT was 0.725 with 95% confidence interval (CI) 0.649\u20130.790 (\n p<\/jats:italic>\n \u2009=\u20090.000), 0.804 with 95% CI 0.740\u20130.856 (\n p<\/jats:italic>\n \u2009=\u20090.000) and 0.197 with 95% CI 0.096\u20130.361 (\n p<\/jats:italic>\n \u2009=\u20090.000), respectively. The diagnostic yield for CRC, advanced adenoma and simple adenoma was 0.058 with 95% CI 0.050\u20130.068 (\n p<\/jats:italic>\n \u2009=\u20090.000), 0.242 with 95% CI 0.188\u20130.306 (\n p<\/jats:italic>\n \u2009=\u20090.000) and 0.147 with 95% CI 0.116\u20130.184 (\n p<\/jats:italic>\n \u2009<\u20090.001), respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n Compliance with diagnostic evaluation after a positive FOBT is still suboptimal. Therefore, measures to increase compliance need to be taken given the increased risk of CRC in these patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/2050640619828185","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:10:47Z","timestamp":1549498247000},"page":"424-448","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["The compliance rate for the second diagnostic evaluation after a positive fecal occult blood test: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2831-4402","authenticated-orcid":false,"given":"Rachel","family":"Gingold-Belfer","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Rabin Medical Center Beilinson Hospital Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv 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