{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:27:45Z","timestamp":1793212065858,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Faecal calprotectin (FC) is a marker of mucosal inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to determine the diagnostic accuracy of FC to (a) differentiate between perianal fistulizing Crohn's disease (pCD) and cryptoglandular perianal fistulas; and (b) detect mucosal inflammation in pCD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with active perianal fistulas who had FC measured and a complete ileocolonoscopy within 10 weeks were retrospectively included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010six patients were included (pCD, <jats:italic>n<\/jats:italic>\u2009=\u200937) of whom 19 pCD patients exhibited ulcers. FC was significantly higher in pCD compared to cryptoglandular fistulas (\u00b5g\/g) (708.0 (207.0\u20131705.0) vs 32.0 (23.0\u201377.0), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Area\u2010under\u2010the\u2010curve (AUC) value for FC receiver operating characteristic (ROC) statistics was 0.900. Optimal FC cut\u2010off was\u2009\u2265\u2009150\u2009\u00b5g\/g. To differentiate pCD from cryptoglandular fistulas in the absence of luminal inflammation, optimal cut\u2010off remained\u2009\u2265\u2009150\u2009\u00b5g\/g (AUC\u2009=\u20090.857, sensitivity\u2009=\u20090.81, specificity\u2009=\u20090.89, positive predictive value (PPV)\u2009=\u200993.8% and negative predictive value (NPV)\u2009=\u200970.8%). In pCD, FC was significantly increased in the presence of ulcers (1672.0 vs 238.0, <jats:italic>p<\/jats:italic>\u2009=\u20090.004). Optimal cut\u2010off was\u2009\u2265\u2009250\u2009\u00b5g\/g (AUC\u2009=\u20090.776; sensitivity\u2009=\u20090.89, specificity\u2009=\u20090.56, PPV\u2009\u2010\u200968.0% and NPV\u2009=\u200983.0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FC discriminates pCD from cryptoglandular fistulas, even in the absence of intestinal ulcers. In active pCD, an elevated FC does not accurately predict the presence of ulcers and should be interpreted with caution.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640619834464","type":"journal-article","created":{"date-parts":[[2019,2,24]],"date-time":"2019-02-24T09:25:22Z","timestamp":1551000322000},"page":"496-506","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Diagnostic accuracy of faecal calprotectin in patients with active perianal fistulas"],"prefix":"10.1002","volume":"7","author":[{"given":"Toer W","family":"Stevens","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert R","family":"D'Haens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolijn","family":"Duijvestein","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem A","family":"Bemelman","sequence":"additional","affiliation":[{"name":"Department of Surgery Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christianne J","family":"Buskens","sequence":"additional","affiliation":[{"name":"Department of Surgery Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina B","family":"Gecse","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam UMC University of Amsterdam Amsterdam The 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