{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:24:16Z","timestamp":1792153456549,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Jubil\u00e4umsfonds of the Austrian National Bank","award":["Grant No 11981"],"award-info":[{"award-number":["Grant No 11981"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Transarterial chemoembolization (TACE) affects hepatic perfusion, and might have an impact on portal pressure in patients with hepatocellular carcinoma (HCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this article is to report the secondary outcome \u201chepatic hemodynamics\u201d from the AVATACE trial, a prospective randomized, placebo\u2010controlled trial on the efficacy of conventional TACE in combination with bevacizumab or placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hepatic venous pressure gradient (HVPG) was measured at baseline (prior to first TACE), within nine days (\u201cacute effects\u201d), two months (\u201cintermediate effects\u201d) and six months (\u201clong\u2010term effects\u201d) after the first TACE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 28 patients with early\u2010intermediate stage HCC, <jats:italic>n<\/jats:italic>\u2009=\u200920 (71%) had clinically significant portal hypertension (CSPH, HVPG\u2009\u2265\u200910\u2009mmHg) at baseline (median, 12 (interquartile range (IQR): 9\u201319)\u2009mmHg). TACE had neither \u201cacute effects\u201d nor \u201cintermediate effects\u201d on HVPG. However, in 13 patients with available HVPG measurement at month 6, there was a significant increase in HVPG (median, 16 (IQR: 11\u201319)\u2009mmHg) compared with baseline (median, 10 (IQR: 5\u201312)\u2009mmHg; <jats:italic>p<\/jats:italic>\u2009=\u20090.007). Portal hypertension\u2010related complications occurred exclusively in patients with CSPH (8 (40%) vs 0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Repeated TACE was associated with a significant long\u2010term increase in HVPG. This should be considered when deciding whether to continue with TACE or switch to systemic treatment, since CSPH drives the development of complications.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640619840199","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T01:24:22Z","timestamp":1553217862000},"page":"850-858","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Short\u2010 and long\u2010term effects of transarterial chemoembolization on portal hypertension in patients with hepatocellular carcinoma"],"prefix":"10.1002","volume":"7","author":[{"given":"Bernhard","family":"Scheiner","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine III Medical University of Vienna Vienna Austria"},{"name":"Liver Cancer (HCC) Study Group Vienna Medical University of Vienna Vienna Austria"},{"name":"Vienna Hepatic 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