{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:54:03Z","timestamp":1793807643999,"version":"4.6.1"},"reference-count":1,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>This guideline presents recommendations for the management of coeliac disease (CD) and other gluten\u2010related disorders both in adults and children. There has been a substantial increase in the prevalence of CD over the last 50 years and many patients remain undiagnosed. Diagnostic testing, including serology and biopsy, should be performed on a gluten\u2010containing diet. The diagnosis of CD is based on a combination of clinical, serological and histopathological data. In a group of children the diagnosis may be made without biopsy if strict criteria are available. The treatment for CD is primarily a gluten\u2010free diet (GFD), which requires significant patient education, motivation and follow\u2010up. Slow\u2010responsiveness occurs frequently, particularly in those diagnosed in adulthood. Persistent or recurring symptoms necessitate a review of the original diagnosis, exclude alternative diagnoses, confirm dietary adherence (dietary review and serology) and follow\u2010up biopsy. In addition, evaluation to exclude complications of CD, such as refractory CD or lymphoma, should be performed. The guideline also deals with other gluten\u2010related disorders, such as dermatitis herpetiformis, which is a cutaneous manifestation of CD characterized by granular IgA deposits in the dermal papillae. The skin lesions clear with gluten withdrawal. Also, less well\u2010defined conditions such as non\u2010coeliac gluten sensitivity (NCGS) and gluten\u2010sensitive neurological manifestations, such as ataxia, have been addressed. Newer therapeutic modalities for CD are being studied in clinical trials but are not yet approved for use in practice.<\/jats:p>","DOI":"10.1177\/2050640619844125","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T03:20:00Z","timestamp":1555125600000},"page":"583-613","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":907,"title":["European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten\u2010related disorders"],"prefix":"10.1002","volume":"7","author":[{"given":"Abdulbaqi","family":"Al-Toma","sequence":"first","affiliation":[{"name":"Department of Gastroenterology St. Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Volta","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Auricchio","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science Section of Paediatrics University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Castillejo","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Hospital Universitari Sant Joan de Reus Universitat Rovira I Virgili, IISPV Reus Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S","family":"Sanders","sequence":"additional","affiliation":[{"name":"Gastroenterology and Liver Unit Royal Hallamshire Hospital &amp; University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Cellier","sequence":"additional","affiliation":[{"name":"Gastroenterology Department H\u00f4pital Europ\u00e9en Georges Pompidou Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris J","family":"Mulder","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology VU Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut E A","family":"Lundin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"KG Jebsen Coeliac Disease Research Centre University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6]]},"reference":[{"key":"e_1_2_18_2_2","unstructured":"See supplementary material."}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2050640619844125","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/2050640619844125","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2050640619844125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T07:19:10Z","timestamp":1693725550000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1177\/2050640619844125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":1,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1177\/2050640619844125"],"URL":"https:\/\/doi.org\/10.1177\/2050640619844125","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6]]}}}