{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:14:46Z","timestamp":1772237686784,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Alfasigma"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although diverticular disease is a common condition, its effective treatment is challenging in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this article is to assess pharmacological management in different clinical settings of diverticular disease and factors associated with treatment using the Italian registry Registro Malattia Diverticolare (REMAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>At study enrolment, patients were categorised into subgroups: diverticulosis, symptomatic uncomplicated diverticular disease and previous diverticulitis. We registered demographic, clinical and lifestyle factors, quality of life and the use of treatments for diverticular disease in the last year. Logistic regression analysis assessed the association between clinical factors and treatment consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 500 of the 1206 individuals included had had at least one treatment for diverticular disease in the last year: 23.6% (166\/702) of patients with diverticulosis, 55.9% (165\/295) of patients with symptomatic diverticular disease, and 80.9% (169\/209) of patients with previous diverticulitis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In multivariate analysis, the following factors were significantly associated with treatment use: female gender, family history of colonic diverticula, organic digestive comorbidity and impaired physical quality of life components.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Individuals with diverticular disease take medications based on the different clinical settings of disease. We identified different features associated with treatment use in the distinct clinical entities of diverticular disease.<\/jats:p><jats:p><jats:bold>ClinicalTrial.gov Identifier:<\/jats:bold> NCT03325829.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640619845990","type":"journal-article","created":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T13:59:51Z","timestamp":1555768791000},"page":"815-824","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Italian nationwide survey of pharmacologic treatments in diverticular disease: Results from the REMAD registry"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7777-2936","authenticated-orcid":false,"given":"Cesare","family":"Cremon","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences Centre for Applied Biomedical Research University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilia","family":"Carabotti","sequence":"additional","affiliation":[{"name":"Medical-Surgical Department of Clinical Sciences and Translational Medicine University Sapienza Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Cuomo","sequence":"additional","affiliation":[{"name":"Sant\u2019Anna and San Sebastiano Hospital Gastroenterology and Digestive Endoscopy Unit Caserta Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Pace","sequence":"additional","affiliation":[{"name":"Unit of Gastroenterology \u201cBolognini\u201d Hospital Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Andreozzi","sequence":"additional","affiliation":[{"name":"Sant\u2019Anna and San Sebastiano Hospital Gastroenterology and Digestive Endoscopy Unit Caserta Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Raffaella","family":"Barbaro","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Centre for Applied Biomedical Research University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Annibale","sequence":"additional","affiliation":[{"name":"Medical-Surgical Department of Clinical Sciences and Translational Medicine University Sapienza Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Barbara","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Centre for Applied Biomedical Research University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"REMAD Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0969141314528889"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.10.035"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/2050640614547068"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.194"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.06.020"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.08.002"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/2050640618764953"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1756284818771305"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.7573\/dic.212526"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.07.004"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14152"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31828003f6"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199603000-00003"},{"key":"e_1_2_11_15_2","first-page":"109","article-title":"The quality of life in patients with chronic pancreatitis evaluated using the SF-12 questionnaire: A comparative study with the SF-36 questionnaire","volume":"38","author":"Pezzilli R","year":"2006","journal-title":"Dig Liver Dis"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12758"},{"key":"e_1_2_11_17_2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0300-5089(21)00097-3","article-title":"Natural history of diverticular disease of the colon","volume":"4","author":"Parks TG","year":"1975","journal-title":"Clin Gastroenterol"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15597-9"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00548-13"},{"key":"e_1_2_11_20_2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jinf.2010.11.004","article-title":"Rifaximin intake leads to emergence of rifampin-resistant staphylococci","volume":"62","author":"Valentin T","year":"2011","journal-title":"J Infect"},{"key":"e_1_2_11_21_2","first-page":"119","article-title":"Diagnostic challenges of symptomatic uncomplicated diverticular disease","volume":"63","author":"Cremon C","year":"2017","journal-title":"Minerva Gastroenterol Dietol"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-012-1554-z"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/2050640614563822"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312377"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04606.x"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e318223cb2b"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1159\/000367625"},{"key":"e_1_2_11_28_2","first-page":"C4453","article-title":"Danish national guidelines for treatment of diverticular disease","volume":"59","author":"Andersen JC","year":"2012","journal-title":"Dan Med J"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1515\/pjs-2015-0045"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-015-1370-x"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000669"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12463"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.15403\/jgld.2014.1121.251.srw"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.10.003"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-015-1401-7"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000939"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1318.2003.00458.x"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1159\/000103896"}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2050640619845990","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/2050640619845990","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2050640619845990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T10:38:05Z","timestamp":1693737485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1177\/2050640619845990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1177\/2050640619845990"],"URL":"https:\/\/doi.org\/10.1177\/2050640619845990","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]}}}