{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:15:24Z","timestamp":1793445324352,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Disease heterogeneity, according to the age at onset, has been reported in Crohn\u2019s disease (CD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to compare natural history in CD patients diagnosed \u226417 (early onset (EO)) versus \u226560 (late onset (LO)) years old.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>EO CD and LO CD patients referred to two Italian inflammatory bowel disease (IBD) centres were included. Relevant data comprised sex, current smoking, disease location and behaviour, IBD family history, extra\u2010intestinal manifestations and use of medical\/surgical therapy during the follow\u2010up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 2321 CD patients, 160\u00a0met the inclusion criteria: 92\u00a0in the EO and 68\u00a0in the LO group (mean follow\u2010up 11.7\u2009\u00b1\u20097.7 years). Family history of IBD was more frequent in EO compared to LO CD (26% vs. 4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Ileocolonic, upper gastrointestinal and perianal involvement occurred more frequently in EO compared to LO CD (56% vs. 21%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001; 17% vs. 3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01; and 38% vs. 19%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01, respectively). Progression to complicated disease occurred more frequently in EO CD (40% vs. 10%\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.005), with an increased use of corticosteroids and anti\u2010tumour necrosis factor alpha agents within 10 years since diagnosis (81% vs. 58%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004, and 36% vs. 16%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01, respectively), while the cumulative probability of surgery did not differ between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with EO CD are more likely to develop a more aggressive disease with perianal involvement and a greater use of drug treatment compared to those with LO CD, without carrying an increased need for surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2050640619860661","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:54:08Z","timestamp":1560992048000},"page":"52-58","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Early\u2010onset versus late\u2010onset Crohn\u2019s disease: An Italian cohort study"],"prefix":"10.1002","volume":"8","author":[{"given":"Laura","family":"Cantoro","sequence":"first","affiliation":[{"name":"IBD Unit San Camillo\u2010Forlanini Hospital Rome Italy"},{"name":"Gastroenterologia Aziendale USL Umbria 1 Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6654-4911","authenticated-orcid":false,"given":"Marco Vincenzo","family":"Lenti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine San Matteo Hospital Foundation 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