{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:34:56Z","timestamp":1768286096335,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["179573\/V40"],"award-info":[{"award-number":["179573\/V40"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"crossref","award":["179573\/V40"],"award-info":[{"award-number":["179573\/V40"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Stiftelsen KG Jebsen","award":["SKGJ MED-017"],"award-info":[{"award-number":["SKGJ MED-017"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Plasma cells (PCs) are terminally differentiated B\u2010lymphocytes producing antibodies. In coeliac disease (CeD) there is increased density of PCs in the small\u2010intestinal lesion. Many of these PCs produce disease\u2010specific autoantibodies targeting transglutaminase 2 (TG2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The plasmacytosis of CeD motivated us to study the transcriptional programme of PCs from coeliac gut lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>RNA\u2010seq was performed on the PCs of CeD patients and disease controls, being specific or non\u2010specific for TG2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Being antibody\u2010producing cells, 67% of the PCs\u2019 transcript was aligned to immunoglobulin genes. Strikingly, genes encoding ligands and receptors of chemokines and cytokines were abundant. Higher transcript levels of genes associated with cell activation and immune responses were observed in PCs of CeD patients compared to controls. TG2\u2010specific compared to non\u2010TG2 specific PCs expressed increased levels of CXCR3, CXCL10 and interleukin\u201015; factors that have been implicated in the pathogenesis of CeD yet with production attributed to other cells than PCs. The presence of transcripts of HLA class II and T\u2010cell co\u2010stimulatory molecules suggests that PCs may serve as antigen\u2010presenting cells for CD4\u2009+\u2009helper T cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings shed new light on the biology of intestinal PCs, implicating functions that go beyond the production of immunoglobulins.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640619862461","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T03:55:25Z","timestamp":1562212525000},"page":"1399-1407","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Transcriptional profiling of human intestinal plasma cells reveals effector functions beyond antibody production"],"prefix":"10.1002","volume":"7","author":[{"given":"Omri","family":"Snir","sequence":"first","affiliation":[{"name":"Department of Immunology University of Oslo and Oslo University Hospital-Rikshospitalet Oslo Norway"},{"name":"KG Jebsen Coeliac Disease Research Centre University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chakravarthi","family":"Kanduri","sequence":"additional","affiliation":[{"name":"KG Jebsen Coeliac Disease Research Centre University of Oslo Oslo Norway"},{"name":"Department of Informatics University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knut E A","family":"Lundin","sequence":"additional","affiliation":[{"name":"KG Jebsen Coeliac Disease Research Centre University of Oslo Oslo Norway"},{"name":"Department of Gastroenterology Oslo University Hospital-Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geir Kjetil","family":"Sandve","sequence":"additional","affiliation":[{"name":"KG Jebsen Coeliac Disease Research Centre University of Oslo Oslo Norway"},{"name":"Department of Informatics University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludvig M","family":"Sollid","sequence":"additional","affiliation":[{"name":"Department of Immunology University of Oslo and Oslo University Hospital-Rikshospitalet Oslo Norway"},{"name":"KG Jebsen Coeliac Disease Research Centre University of Oslo Oslo 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