{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:02:51Z","timestamp":1793188971307,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Novintethical Pharma SA","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Irritable bowel syndrome (IBS) is highly prevalent and presents a clinical challenge. Gelsectan is a medical device containing xyloglucan (XG), pea protein and tannins (PPT) from grape seed extract, and xylo\u2010oligosaccharides (XOS), which act together to protect and reinforce the intestinal barrier.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study is to evaluate the efficacy and safety of XG\u2009+\u2009PPT\u2009+\u2009XOS in patients with diarrhoea\u2010predominant IBS (IBS\u2010D).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this double\u2010blind study, 60 patients were randomly assigned to receive XG\u2009+\u2009PPT\u2009+\u2009XOS or placebo for 28 days, then crossed over to the alternative treatment. Patients were followed for 60 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At Day 28, a significantly higher proportion of patients starting treatment with XG\u2009+\u2009PPT\u2009+\u2009XOS than placebo (87 vs 0%; <jats:italic>p<\/jats:italic>\u2009=\u20090.0019) presented normal stools (Bristol Stool Form Scale type 3\u22124). At Day 56, a significantly higher proportion of patients who crossed over to XG\u2009+\u2009PPT\u2009+\u2009XOS than placebo (93% vs 23%; <jats:italic>p<\/jats:italic>\u2009=\u20090.0001) presented normal stools. In the group allocated to receive XG\u2009+\u2009PPT\u2009+\u2009XOS after placebo, benefits of XG\u2009+\u2009PPT\u2009+\u2009XOS were maintained during follow\u2010up. Subjective assessments of abdominal pain, bloating, quality of life and general health indicated significant improvement with XG\u2009+\u2009PPT\u2009+\u2009XOS over placebo. There were no related adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>XG\u2009+\u2009PPT\u2009+\u2009XOS effectively controlled diarrhoea and alleviated clinical symptoms in patients with IBS\u2010D, and was well tolerated.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640619862721","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T03:55:25Z","timestamp":1562212525000},"page":"1093-1101","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":52,"title":["Efficacy and safety of Gelsectan for diarrhoea\u2010predominant irritable bowel syndrome: A randomised, crossover clinical trial"],"prefix":"10.1002","volume":"7","author":[{"given":"Anca","family":"Trifan","sequence":"first","affiliation":[{"name":"SC Gastromedica SRL Iasi 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