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Entry criteria constituted one or more of three alarm features: anaemia, visible rectal bleeding, or change in bowel habit for more than 4 weeks in patients over 40 years of age. Patients were grouped as having only change in bowel habit, change in bowel habit plus anaemia\/bleeding or anaemia\/bleeding only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 628 patients, 22% were diagnosed with colorectal cancer. There were no cases of colorectal cancer in the only change in bowel habit group under 55 years, while this was 6% for 55\u201364 years, 8% for 65\u201374 years and 14% for 75 years and older. Among subjects under 55 years, 2% with anaemia\/bleeding had colorectal cancer, this increased to 34% for 55 years and older (<jats:italic>P<\/jats:italic> \u2009&lt;\u20090.0001). Change in bowel habit plus anaemia\/bleeding gave a colorectal cancer prevalence of 16% in under 55 years and increased to 30% for 55 years and older (<jats:italic>P<\/jats:italic> \u2009=\u20090.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Change in bowel habit as the only alarm feature has a low diagnostic yield for colorectal cancer in patients under 55 years.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640619888040","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T04:55:10Z","timestamp":1573102510000},"page":"211-219","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["The diagnostic value of a change in bowel habit for colorectal cancer within different age groups"],"prefix":"10.1002","volume":"8","author":[{"given":"Sofia M","family":"McCulloch","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annikka V","family":"Polster","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas\u2010Bernd","family":"Pischel","sequence":"additional","affiliation":[{"name":"Sahlgrenska University Hospital Sahlgrenska Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"St\u00e5lsmeden","sequence":"additional","affiliation":[{"name":"Kung\u00e4lv Hospital Kung\u00e4lv Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Shafazand","sequence":"additional","affiliation":[{"name":"Sahlgrenska University Hospital \u00d6stra Hospital othenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Block","sequence":"additional","affiliation":[{"name":"Sahlgrenska University Hospital \u00d6stra Hospital othenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Byr\u00f6d","sequence":"additional","affiliation":[{"name":"Sahlgrenska University Hospital M\u00f6lndal Hospital M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Lindkvist","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition University of Gothenburg Gothenburg Sweden"},{"name":"Sahlgrenska University Hospital Sahlgrenska Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"T\u00f6rnblom","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition University of Gothenburg Gothenburg Sweden"},{"name":"Sahlgrenska University Hospital Sahlgrenska Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00f6rje","family":"Jonefj\u00e4ll","sequence":"additional","affiliation":[{"name":"Kung\u00e4lv Hospital Kung\u00e4lv Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Simren","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition University of Gothenburg Gothenburg Sweden"},{"name":"Sahlgrenska University Hospital Sahlgrenska Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"International Agency for Research on Cancer (WHO).GLOBOCAN 2012: Estimated Cancer Incidence Mortality and Prevalence in 2012.http:\/\/globocan.iarc.fr\/Pages\/fact_sheets_population.aspx(accessed 21 August 2019)."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy033"},{"key":"e_1_2_11_4_1","unstructured":"Cancer Research UK.Bowel cancer incidence statistics.www.cancerresearchuk.org\/health\u2010professional\/cancer\u2010statistics\/statistics\u2010by\u2010cancer\u2010type\/bowel\u2010cancer\/incidence(accessed 21 August 2019)."},{"key":"e_1_2_11_5_1","unstructured":"National Cancer Institute SEER.Colon and rectum cancer (Invasive) trends in SEER incidence and U.S. mortality using the joinpoint regression program 1975\u20132003 with up to three joinpoints by race and sex: National Cancer Institute; 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