{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:15:25Z","timestamp":1791134125589,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/This"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recommendations for the duration of antimicrobial therapy in cholangitis after successful endoscopic biliary drainage vary. The aim of this study was to compare the occurrence of local infectious complications in patients with acute cholangitis treated with antibiotics for 3\u00a0days or less compared with 4\u00a0days or more.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective multicentre study in seven hospitals in the Netherlands. Patients who received a successful biliary drainage by endoscopic retrograde cholangio\u2010pancreatography because of cholangitis due to common bile duct stones between 2012 and 2017 were included. The primary outcome was the occurrence of a local infectious complication within 3\u00a0months of endoscopic retrograde cholangio\u2010pancreatography. Secondary outcomes included <jats:italic>Clostridioides difficile<\/jats:italic> infection, total length of hospital stay and all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 426 patients with cholangitis were identified and 296 patients met all inclusion criteria. Therapy duration was \u22643\u00a0days in 137 patients (46.3%). During follow\u2010up, 41 patients (13.9%) developed a local infectious complication. Occurrence of infectious complications did not differ between the two groups (<jats:italic>p<\/jats:italic> \u2009=\u20090.32). No patient developed <jats:italic>Clostridioides difficile<\/jats:italic> infection. Median hospital stay was 6\u00a0days (interquartile range 4\u20138\u00a0days) in the short antibiotic group compared with 7\u00a0days (interquartile range 5\u20139\u00a0days) in the long group (<jats:italic>p<\/jats:italic> \u2009=\u20090.03). Four (1.4%) patients died during follow\u2010up, all were treated for \u22654\u00a0days (<jats:italic>p<\/jats:italic> \u2009=\u20090.13<jats:italic>).<\/jats:italic><\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Antimicrobial therapy of 3\u00a0days or less seems to be sufficient after successful biliary drainage in patients with acute cholangitis. Randomized trials should confirm our findings.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640620915016","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T05:08:57Z","timestamp":1584508137000},"page":"481-488","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Antimicrobial therapy of 3\u00a0days or less is sufficient after successful ERCP for acute cholangitis"],"prefix":"10.1002","volume":"8","author":[{"given":"Sylke","family":"Haal","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam UMC University of Amsterdam Amsterdam Gastroenterology and Metabolism Amsterdam Netherlands"},{"name":"Department of Internal medicine Spaarne Gasthuis Hoofddorp Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt","family":"ten B\u00f6hmer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam UMC University of Amsterdam Amsterdam Gastroenterology and Metabolism Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiaan","family":"Balkema","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Dijklander Ziekenhuis Hoorn Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annekatrien CTM","family":"Depla","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology MC Slotervaart Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Fockens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam UMC University of Amsterdam Amsterdam Gastroenterology and Metabolism Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen M","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology OLVG Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd D","family":"Kuiken","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology OLVG Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris I","family":"Liberov","sequence":"additional","affiliation":[{"name":"Department of Internal medicine Zaans Medisch Centrum Zaandam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellert","family":"van Soest","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Spaarne Gasthuis Hoofddorp Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanin E","family":"van Hooft","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam UMC University of Amsterdam Amsterdam Gastroenterology and Metabolism Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elske","family":"Sieswerda","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infection Control Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogier P","family":"Voermans","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam UMC University of Amsterdam Amsterdam Gastroenterology and Metabolism Amsterdam 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