{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:13:40Z","timestamp":1775092420263,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Background and aims<\/jats:title><jats:p>Several studies have shown improved short\u2010term outcome with endoscopic transmural drainage and necrosectomy for the treatment of walled\u2010off pancreatic necrosis. However, knowledge on the long\u2010term prognosis after such treatment is limited. The aim of present study was to evaluate long\u2010term outcomes in patients endoscopically treated with transmural drainage and necrosectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively follow up 125 patients with walled\u2010off pancreatic necrosis treated with endoscopic transmural drainage and necrosectomy in 2010\u20132017. All patients received plastic pigtail stents and nasocystic catheter. Additional external drainage was performed in 41 patients. Main outcomes were survival, pancreatic function, development of co\u2010morbidities, ability to work and social status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median follow\u2010up of 4.3 years, nine (7%) patients died. Seven deaths were unrelated to pancreatic disease, and two patients died of pancreatic cancer. Twenty\u2010two (18%) patients developed exocrine pancreatic insufficiency. Thirty\u2010six (32%) previous non\u2010diabetics developed endocrine insufficiency. Endoscopic necrosectomy during admission (odds ratio (OR)\u2009=\u20091.28, 95% confidence interval (CI) 1.05\u20131.56; <jats:italic>p<\/jats:italic> \u2009=\u20090.015) and therapy on the main pancreatic duct (OR\u2009=\u20098.08, 95% CI 2.43\u201326.9; <jats:italic>p<\/jats:italic> \u2009&lt;\u20090.001) during follow\u2010up predicted development of exocrine insufficiency. Severity on computed tomography predicted endocrine insufficiency (OR\u2009=\u20091.61, 95% CI 1.24\u20132.09; <jats:italic>p<\/jats:italic> \u2009&lt;\u20090.001). Most patients regained their working capacity and preserved their marital status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides robust data on the long\u2010term outcome of patients with walled\u2010off pancreatic necrosis treated with endoscopic transmural drainage and necrosectomy. The favourable outcomes on survival, pancreatic function and social status support current recommendations of endoscopic transmural drainage and necrosectomy being the treatment of choice for walled\u2010off pancreatic necrosis.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640620916029","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T03:10:46Z","timestamp":1587697846000},"page":"552-558","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Endoscopic treatment with transmural drainage and necrosectomy for walled\u2010off necrosis provides favourable long\u2010term outcomes on pancreatic function"],"prefix":"10.1002","volume":"8","author":[{"given":"Andreas","family":"Bartholdy","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Surgery Hvidovre University Hospital Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikkel","family":"Werge","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Surgery Hvidovre University Hospital Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srdan","family":"Novovic","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Surgery Hvidovre University Hospital Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9481-6021","authenticated-orcid":false,"given":"Amer","family":"Hadi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Surgery Hvidovre University Hospital Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"N\u00f8jgaard","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Surgery Hvidovre University Hospital Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Borch","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Surgery Hvidovre University Hospital Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Feldager","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Surgery Hvidovre University Hospital Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise Lotte","family":"Gluud","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Surgery Hvidovre University Hospital Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Palle Nordblad","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Surgery Hvidovre University Hospital Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302779"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.946078"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908821"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2013.07.063"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32404-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5049.79879"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.174.2.2296641"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.183.5.1831261"},{"key":"e_1_2_10_11_1","unstructured":"World Health Organization. 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