{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:54:51Z","timestamp":1785419691082,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Secondary sclerosing cholangitis in critically ill patients (SSC\u2010CIP) is an emerging disease with grim prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our aim was the analysis of prognostic factors, long\u2010term outcome and risk of tumour development in SSC\u2010CIP compared with primary sclerosing cholangitis (PSC) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis between 2008 and 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and eleven patients with SSC\u2010CIP and 408\u00a0PSC patients were identified. Median orthotopic liver transplantation (OLT)\u2010free survival was 16\u00a0months for SSC\u2010CIP and 147\u00a0months for PSC (<jats:italic>p<\/jats:italic> \u2009&lt;\u20090.001). OLT was performed in 18\/111 SSC\u2010CIP compared with 166\/408\u00a0PSC patients (<jats:italic>p<\/jats:italic> \u2009&lt;\u20090.001). Malignant tumours were detected in 17.9% of PSC patients (73\/408) compared with 2.7% (3\/111) in SSC\u2010CIP (<jats:italic>p<\/jats:italic> \u2009&lt;\u20090.001). In multivariate Cox regression analysis low levels of C\u2010reactive protein (hazard ratio 4.687 (95% confidence interval (CI) 1.144\u201319.199, <jats:italic>p<\/jats:italic> \u2009=\u20090.032) were significantly associated with a prolonged survival whereas higher age (hazard ratio 0.488 (95% CI 0.23\u20131.038), <jats:italic>p<\/jats:italic> \u2009=\u20090.062) showed a trend for shorter survival in SSC\u2010CIP. For PSC malignancies (hazard ratio 0.42 (95% CI 0.313\u20130.575), <jats:italic>p<\/jats:italic> \u2009&lt;\u20090.001) and higher age (hazard ratio 0.709 (95% CI 0.544\u20130.922), <jats:italic>p<\/jats:italic> \u2009=\u20090.01) were associated with a shorter OLT\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SSC\u2010CIP is characterized by acute onset of liver disease and poor prognosis but with lower tumour incidence compared with PSC.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640620924274","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T02:09:55Z","timestamp":1588644595000},"page":"716-724","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Secondary sclerosing cholangitis in critically ill patients has a poor outcome but lower tumour incidence than primary sclerosing cholangitis"],"prefix":"10.1002","volume":"8","author":[{"given":"Martha M","family":"Kirstein","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Book","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P","family":"Manns","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"von Hahn","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School Hannover 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