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IgG4\u2010related digestive disease can be diagnosed only with a comprehensive work\u2010up that includes histology, organ morphology at imaging, serology, search for other organ involvement, and response to glucocorticoid treatment. Indications for treatment are symptomatic patients with obstructive jaundice, abdominal pain, posterior pancreatic pain, and involvement of extra\u2010pancreatic digestive organs, including IgG4\u2010related cholangitis. Treatment with glucocorticoids should be weight\u2010based and initiated at a dose of 0.6\u20130.8\u00a0mg\/kg body weight\/day orally (typical starting dose 30\u201040\u00a0mg\/day prednisone equivalent) for 1\u00a0month to induce remission and then be tapered within two additional months. Response to initial treatment should be assessed at week 2\u20134 with clinical, biochemical and morphological markers. Maintenance treatment with glucocorticoids should be considered in multi\u2010organ disease or history of relapse. 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