{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:44:05Z","timestamp":1792021445588,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100008985","name":"Deutsche Morbus Crohn\/Colitis Ulcerosa Vereinigung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008985","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008985","name":"Deutsche Morbus Crohn\/Colitis Ulcerosa Vereinigung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008985","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>Physical activity is beneficial in several chronic disorders including Crohn\u2032s disease, but the preferred type of exercise is unknown. Our study aimed to examine and compare the safety, feasibility and potential beneficial effects of individual moderate endurance and moderate muscle training in patients with Crohn\u2019s disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Quiescent or mildly active (Crohn\u2019s disease activity index &lt;220) patients with Crohn\u2019s disease were randomly allocated to either a control, endurance, or muscle training group. Participants exercised individually for 3\u00a0months three times per week. Endpoints included dropout rate, disease activity, inflammatory parameters including faecal calprotectin, anthropometric data, quality of life, physical activity and strength.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 45 patients with Crohn\u2019s disease were randomly allocated. In the endurance group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200917), the dropout rate was significantly higher (47% vs. 13%) compared with the muscle group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915). In both groups the maximal and average strength in the upper and lower extremities increased significantly (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.04). In the endurance group emotional function was significantly improved (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03). Statistically significant changes of disease activity and other outcome parameters were not observed in this pilot cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both individual moderate endurance and muscle training can be safely performed in patients with mild or quiescent Crohn\u2019s disease. Muscle training appears more feasible and may be favoured. Both forms of exercise have beneficial effects on strength. Quality of life increased in both intervention groups, although statistical significance was only reached in one subgroup.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2050640620936383","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T03:21:03Z","timestamp":1593055263000},"page":"804-813","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["Moderate endurance and muscle training is beneficial and safe in patients with quiescent or mildly active Crohn\u2019s disease"],"prefix":"10.1002","volume":"8","author":[{"given":"Wolfgang Alexander","family":"Seeger","sequence":"first","affiliation":[{"name":"Department of Medicine I Agaplesion Markus Hospital Frankfurt Germany"},{"name":"Medical Department I (Gastroenterology, Infectiology, and Rheumatology) Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Thieringer","sequence":"additional","affiliation":[{"name":"Department of Medicine I Agaplesion Markus Hospital Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Esters","sequence":"additional","affiliation":[{"name":"Department of Medicine I Agaplesion Markus Hospital Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Allmendinger","sequence":"additional","affiliation":[{"name":"Department of Medicine I Agaplesion Markus Hospital Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3558-3341","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Clinical Nutrition Interdisziplin\u00e4res Crohn Colitis Centrum Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Schulze","sequence":"additional","affiliation":[{"name":"Department of Medicine I Agaplesion Markus Hospital Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-054X","authenticated-orcid":false,"given":"Axel","family":"Dignass","sequence":"additional","affiliation":[{"name":"Department of Medicine I Agaplesion Markus Hospital Frankfurt Germany"},{"name":"Medical Department I (Gastroenterology, Infectiology, and Rheumatology) Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs207"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4478-5"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527313666140612102841"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v8.i10.575"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz051"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","unstructured":"LoCH KhaliliH SongM et al. 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