{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:21:08Z","timestamp":1791991268822,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,1,12]],"date-time":"2020-01-12T00:00:00Z","timestamp":1578787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,1,12]],"date-time":"2020-01-12T00:00:00Z","timestamp":1578787200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A simplified magnetic resonance enterography (MRe) index (sMARIA) for Crohn\u2019s disease (CD) was recently developed and validated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our aims were (a) to assess sMARIA\u2019s accuracy in a sample other than the validation cohort; (b) to evaluate its correlation with a simpler endoscopy index (SES\u2010CD) and fecal calprotectin (FC); and (c) to assess the need of an expert radiologist to reliably use sMARIA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with CD who underwent MRe, ileocolonoscopy and FC within 2\u20134 weeks had their MRe retrospectively reviewed by two blinded raters. Disease activity was evaluated through sMARIA, SES\u2010CD and FC. sMARIA\u2019s accuracy, indices correlation, and interrater reliability were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 84 patients were included, comprising 420\u00a0intestinal segments evaluations. sMARIA \u22651 accurately identified segments with active disease (90% sensitivity, 98% specificity; area under the curve 0.94, 95% confidence interval (CI) 0.91\u20130.97;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). sMARIA correlated with endoscopy, both for ileal and colonic segments (R\u2009=\u20090.94 and R\u2009=\u20090.82;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Per patient, there was a strong correlation between sMARIA, endoscopy (R\u2009=\u20090.95;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and FC (R\u2009=\u20090.91;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Interrater agreement was excellent (intraclass correlation coefficient 0.95; 95% CI 0.94\u20130.96;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>sMARIA accurately measured CD activity using SES\u2010CD as standard of reference, and exhibited high correlation with a simple endoscopic index and a biomarker. The interrater reliability between a radiology resident and an expert was excellent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2050640620943089","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T02:50:23Z","timestamp":1594781423000},"page":"1208-1216","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":58,"title":["The new simplified MARIA score applies beyond clinical trials: A suitable clinical practice tool for Crohn\u2019s disease that parallels a simple endoscopic index and fecal calprotectin"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5098-8729","authenticated-orcid":false,"given":"Joana","family":"Roseira","sequence":"first","affiliation":[{"name":"Gastroenterology Department Centro Hospitalar Universit\u00e1rio do Algarve Portim\u00e3o Portugal"},{"name":"ABC \u2013 Algarve Biomedical Center Portim\u00e3o Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Rita","family":"Ventosa","sequence":"additional","affiliation":[{"name":"ABC \u2013 Algarve Biomedical Center Portim\u00e3o Portugal"},{"name":"Radiology Department Centro Hospitalar Universit\u00e1rio do Algarve Portim\u00e3o Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Tavares","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Centro Hospitalar Universit\u00e1rio do Algarve Portim\u00e3o Portugal"},{"name":"ABC \u2013 Algarve Biomedical Center Portim\u00e3o Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Brito","sequence":"additional","affiliation":[{"name":"ABC \u2013 Algarve Biomedical Center Portim\u00e3o Portugal"},{"name":"Radiology Department Centro Hospitalar Universit\u00e1rio do Algarve Portim\u00e3o Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy113"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000440"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","unstructured":"NehraAK SheedySP WellsML et al.Imaging findings of ileal inflammation at computed tomography and magnetic resonance enterography: What do they mean when ileoscopy and biopsy are negative? 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