{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:35:41Z","timestamp":1787654141523,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>Alcoholic hepatitis should be suspected in every patient with excessive chronic alcohol consumption and recent onset of jaundice. Diagnosis of alcoholic hepatitis is based on clinical and laboratory findings, and confirmed by a liver biopsy when available. Several scores are available to assess severity and prognosis of alcoholic hepatitis. The 1\u2010month mortality of patients with severe alcoholic hepatitis, as defined by Maddrey\u2019s discriminant function, is 20\u201330%. Therefore, severe alcoholic hepatitis should be treated with a 28\u2010day course of oral prednisolone after systematic screening for infection. In this review, we discuss diagnosis of alcoholic hepatitis, the different scores to assess severity of the disease, indications for corticosteroid therapy and alternative therapeutic options for non\u2010responders to medical therapy.<\/jats:p>","DOI":"10.1177\/2050640620945886","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T07:03:23Z","timestamp":1595919803000},"page":"995-1002","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Alcoholic hepatitis: Towards an era of personalised management"],"prefix":"10.1002","volume":"8","author":[{"given":"Delphine","family":"Degr\u00e9","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hepatopancreatology and Digestive Oncology Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line C Ntandja","family":"Wandji","sequence":"additional","affiliation":[{"name":"Service des maladies de l\u2019appareil digestif Universit\u00e9 Lille Nord de France Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatopancreatology and Digestive Oncology Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Louvet","sequence":"additional","affiliation":[{"name":"Service des maladies de l\u2019appareil digestif Universit\u00e9 Lille Nord de France Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.018"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412278"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8964410"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00289-6"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.12.023"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.07.016"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.042"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040605"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29080"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.09.011"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20503"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.050781"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.099226"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02104.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.017"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15335"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.01.018"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000492"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(78)90401-8"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.04.062"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.05.011"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.06.006"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30866"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21607"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.224097"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.20189"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1101214"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.12.038"},{"key":"e_1_2_10_30_1","unstructured":"McClainCJ VatsalyaV HassaneinTI et al.DUR\u2010928 therapy for acute alcoholic hepatitis: A pilot study. The Liver Meeting 2019 November 8\u201012 Boston 2019. Hepatology 2019; 70: S1 Abstract 1376."},{"key":"e_1_2_10_31_1","article-title":"An open\u2010label, dose\u2010escalation study to assess the safety and efficacy of IL\u201022 agonist F\u2010652\u00a0in patients with alcohol\u2010associated hepatitis","author":"Arab JP","journal-title":"Hepatology"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22317"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.154"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.35"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.10.029"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1742-x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105703"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.04.009"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13586"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21298"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25544"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.04.012"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29338"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29240"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61814-5"}],"container-title":["United European Gastroenterology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2050640620945886","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/2050640620945886","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2050640620945886","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T14:02:00Z","timestamp":1693749720000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1177\/2050640620945886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1177\/2050640620945886"],"URL":"https:\/\/doi.org\/10.1177\/2050640620945886","archive":["Portico"],"relation":{},"ISSN":["2050-6406","2050-6414"],"issn-type":[{"value":"2050-6406","type":"print"},{"value":"2050-6414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11]]}}}