{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:02:54Z","timestamp":1775149374980,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Biologically na\u00efve patients with inflammatory bowel disease treated with vedolizumab (VDZ) are largely underrepresented in real\u2010world cohorts. A multi\u2010centre, observational cohort study was performed on the effectiveness and safety of VDZ in biologically na\u00efve subjects with Crohn\u2019s disease (CD) and ulcerative colitis (UC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of consecutive biologically na\u00efve patients with CD and UC treated with VDZ from July 2016 to December 2019 were extracted from the cohort of the Sicilian Network for Inflammatory Bowel Disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 172 consecutive patients (CD: <jats:italic>N<\/jats:italic> \u2009=\u200988; UC: <jats:italic>N<\/jats:italic> \u2009=\u200984; median age 66.0 years) were included, with a median follow\u2010up of 58.8 weeks. After 14 weeks, a clinical response was reported in 68.2% of patients with CD and 67.9% of patients with UC treated with VDZ, including 45.5% patients in the CD group and 46.4% patients in the UC group who achieved steroid\u2010free remission. After 52 weeks, a clinical response was reported in 77.4% of CD and in 73.8% of UC patients treated with VDZ, including 59.7% patients in the CD group and 60.7% patients in the UC group who achieved steroid\u2010free remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates the effectiveness and safety of VDZ as a first\u2010line biological, particularly among elderly patients.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640620948802","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T05:40:00Z","timestamp":1597038000000},"page":"1045-1055","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Effectiveness and safety of vedolizumab in biologically na\u00efve patients: A real\u2010world multi\u2010centre study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5128-3846","authenticated-orcid":false,"given":"Fabio Salvatore","family":"Macaluso","sequence":"first","affiliation":[{"name":"Inflammatory Bowel Disease Unit AOOR \u2018Villa Sofia\u2010Cervello\u2019 Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Fries","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Unit AOU Policlinico \u2018G. 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