{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:34:04Z","timestamp":1780616044013,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Superficial oesophageal adenocarcinoma can be resected endoscopically, but data to define a curative endoscopic resection are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our study aimed to assess the risk of lymph node metastasis depending on the depth of invasion and histological features of oesophageal adenocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively included all patients undergoing an endoscopic resection for T1 oesophageal adenocarcinoma among seven expert centres in France in 2004\u20132016. Mural invasion was defined as either intramucosal or submucosal tumours; the latter were further divided into superficial submucosal (&lt;1000\u00a0mm) and deep submucosal (&gt;1000\u00a0mm). Absence or presence of lymphovascular invasion and\/or poorly differentiated cancer (G3) defined a low\u2010risk or a high\u2010risk tumour, respectively. For submucosal tumours, invasion depth and histological features were systematically confirmed after a second dedicated histological assessment (new 2\u2010mm thick slices) performed by a second pathologist. Occurrence of lymph node metastasis was recorded during the follow\u2010up from histological or PET CT reports when an invasive procedure was not possible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 188 superficial oesophageal adenocarcinomas were included with a median follow\u2010up of 34\u00a0months. No lymph node metastases occurred for intramucosal oesophageal adenocarcinomas (<jats:italic>n<\/jats:italic>\u00a0=\u00a0135) even with high\u2010risk histological features. Among submucosal oesophageal adenocarcinomas, only tumours with lymphovascular invasion or poorly differentiated cancer or with a depth of invasion &gt;1000\u00a0\u03bcm developed lymph node metastasis tumours (<jats:italic>n<\/jats:italic>\u00a0=\u00a010\/53%; 18.9%; hazard ratio 12.04). No metastatic evolution occurred under a 1000\u2010mm threshold for all low\u2010risk tumours (0\/25), nor under 1200\u00a0mm (0\/1) and three over this threshold (3\/13%, 23.1%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intramucosal and low\u2010risk tumours with shallow submucosal invasion up to 1200\u00a0mm were not associated with lymph node metastasis during follow\u2010up. In case of high\u2010risk features and\/or deep submucosal invasion, endoscopic resections are not sufficient to eliminate the risk of lymph node metastasis, and surgical oesophagectomy should be carried out. These results must be confirmed by larger prospective series.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640620958903","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T18:23:41Z","timestamp":1599675821000},"page":"362-369","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Endoscopic resection of Barrett's adenocarcinoma: Intramucosal and low\u2010risk tumours are not associated with lymph node metastases"],"prefix":"10.1002","volume":"9","author":[{"given":"Nicolas","family":"Benech","sequence":"first","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastroent\u00e9rologie H\u00f4pital Edouard Herriot Hospices civils de Lyon  Lyon France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Marc","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Claude 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