{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:45:37Z","timestamp":1790070337488,"version":"4.0.1"},"reference-count":54,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T00:00:00Z","timestamp":1381795200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Vaccines"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p> Dengue is a mosquito-borne disease which is currently an expanding global health problem. The disease is caused by four closely related viruses, the dengue virus. There are no specific dengue therapeutics and prevention is currently limited to vector control measures. Development of an effective tetravalent dengue vaccine would therefore represent a major advance in the control of the disease and is considered a high public health priority. While a licensed dengue vaccine is not yet available, the scope and intensity of dengue vaccine development has increased dramatically in the last decade. The uniqueness of the dengue viruses and the spectrum of disease resulting from infection have made dengue vaccine development difficult. Several vaccine candidates are currently being evaluated in clinical studies. The candidate currently at the most advanced clinical development stage, a live-attenuated tetravalent vaccine based on chimeric yellow fever dengue virus, has progressed to phase III efficacy studies. Several other live-attenuated vaccines, as well as subunit, DNA and purified inactivated vaccine candidates, are at earlier stages of clinical development. Additional technological approaches, such as virus-vectored and virus-like particle-based vaccines, are under evaluation in preclinical studies. <\/jats:p>","DOI":"10.1177\/2051013613507862","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T04:32:43Z","timestamp":1381897963000},"page":"3-9","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":81,"title":["Latest developments and future directions in dengue vaccines"],"prefix":"10.1177","volume":"2","author":[{"given":"Usa","family":"Thisyakorn","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Road, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chule","family":"Thisyakorn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,10,15]]},"reference":[{"key":"bibr1-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2000.13.179"},{"key":"bibr2-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.07.100"},{"key":"bibr3-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.12.016"},{"key":"bibr4-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiq022"},{"key":"bibr5-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.11.050"},{"key":"bibr6-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00040-2"},{"key":"bibr7-2051013613507862","first-page":"367","volume":"44","author":"Blac G.","year":"1930","journal-title":"Ann Inst Pasteur Paris"},{"key":"bibr8-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2000.0239"},{"key":"bibr9-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.05.058"},{"key":"bibr10-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2011.573624"},{"key":"bibr11-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.12.5477-5485.2000"},{"key":"bibr12-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.9.4761-4775.2004"},{"key":"bibr13-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.06.094"},{"key":"bibr14-2051013613507862","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2003.69.6_suppl.0690005"},{"key":"bibr15-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4557-0090-5.00047-1"},{"key":"bibr16-2051013613507862","first-page":"90","volume":"1","author":"Hemungkorn M.","year":"2007","journal-title":"Biosci Trends"},{"key":"bibr17-2051013613507862","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2006.75.986"},{"key":"bibr18-2051013613507862","first-page":"7","author":"Huang C.","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"bibr19-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.5.6.803"},{"key":"bibr20-2051013613507862","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2002.67.260"},{"key":"bibr21-2051013613507862","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2004.70.89"},{"key":"bibr22-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1007\/BF00870272"},{"key":"bibr23-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00446-7"},{"key":"bibr24-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.12.5139"},{"key":"bibr25-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064595"},{"key":"bibr26-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1089\/10430349950018517"},{"key":"bibr27-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1086\/527328"},{"key":"bibr28-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1997.8.3-293"},{"key":"bibr29-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.01.011"},{"key":"bibr30-2051013613507862","unstructured":"National Institutes of Health (2013) Study of HBV-001 D1 in healthy adults. http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00936429 (accessed 22 September 2013)."},{"key":"bibr31-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1995.tb44729.x"},{"key":"bibr32-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1089\/10430349950018508"},{"key":"bibr33-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.7.5366-5374.1997"},{"key":"bibr34-2051013613507862","first-page":"26","volume":"3","author":"Prommalikit O.","year":"2004","journal-title":"Asian Oceanian J Paediatr Child Health"},{"key":"bibr35-2051013613507862","author":"Prommalikit O.","year":"2013","journal-title":"Asian Biomed"},{"key":"bibr36-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.05.005"},{"key":"bibr37-2051013613507862","first-page":"285","volume":"1","author":"Rice C.","year":"1989","journal-title":"New Biol"},{"key":"bibr38-2051013613507862","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2002.66.264"},{"key":"bibr39-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000109289.55856.27"},{"key":"bibr40-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61428-7"},{"key":"bibr41-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.03.066"},{"key":"bibr42-2051013613507862","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2000.62.698"},{"key":"bibr43-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.10.023"},{"key":"bibr44-2051013613507862","first-page":"1","volume":"44","author":"Simmons J.","year":"1931","journal-title":"Philippine J Sci"},{"key":"bibr45-2051013613507862","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1995.53.432"},{"key":"bibr46-2051013613507862","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2003.69.6_suppl.0690024"},{"key":"bibr47-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.05.087"},{"key":"bibr48-2051013613507862","unstructured":"Thisyakorn U., Capeding M., Hadinegoro S., Zulkifli I., Tantwichien T., Goh D. (2013) Preparing for dengue vaccine introduction: recommendations from the 1st ADVA Regional Workshop (submitted)."},{"key":"bibr49-2051013613507862","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.12-0361"},{"key":"bibr50-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1142\/9781848162297_0004"},{"key":"bibr51-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2013.05.014"},{"key":"bibr52-2051013613507862","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-20-37"},{"key":"bibr53-2051013613507862","doi-asserted-by":"publisher","DOI":"10.3201\/eid0203.960302"},{"key":"bibr54-2051013613507862","volume-title":"Dengue Vaccine Development: The Role of the WHO South-East Asia Regional Office","author":"World Health Organization","year":"2010"}],"container-title":["Therapeutic Advances in Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2051013613507862","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2051013613507862","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2051013613507862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T09:18:04Z","timestamp":1740820684000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2051013613507862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,15]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1177\/2051013613507862"],"URL":"https:\/\/doi.org\/10.1177\/2051013613507862","relation":{},"ISSN":["2051-0144","2051-0136"],"issn-type":[{"value":"2051-0144","type":"print"},{"value":"2051-0136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,15]]}}}