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A number of different vaccine platforms are being developed by assessing preclinical efficacy in animal models and expediting clinical development. Over 15 different vaccines are in preclinical development and 8 vaccines are now in different stages of clinical evaluation. These vaccines include DNA vaccines, virus-like particles and viral vectors such as live replicating vesicular stomatitis virus (rVSV), human and chimpanzee adenovirus, and vaccinia virus. Recently, in preliminary results reported from the first phase III trial of an Ebola vaccine, the rVSV-vectored vaccine showed promising efficacy. This review charts this rapidly advancing area of research focusing on vaccines in clinical development and discusses the future opportunities and challenges faced in the licensure and deployment of Ebola vaccines.<\/jats:p>","DOI":"10.1177\/2051013615611017","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T21:02:28Z","timestamp":1444942948000},"page":"125-138","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":74,"title":["Clinical development of Ebola vaccines"],"prefix":"10.1177","volume":"3","author":[{"given":"Saranya","family":"Sridhar","sequence":"first","affiliation":[{"name":"Jenner Institute, University of Oxford, Oxford OX3 7DQ, 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