{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:28:38Z","timestamp":1790634518326,"version":"4.1.0"},"reference-count":40,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Caress Flow"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Post Reprod Health"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Genitourinary syndrome of menopause (GSM) is a condition affecting many postmenopausal women. Among the available treatments, the vaginal natural oxygenation device (VNOD) is a new promising option.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To evaluate the safety and the effectiveness of vaginal high concentration (HC) oxygen (O\n                      <jats:sub>2<\/jats:sub>\n                      ) and hyaluronic acid (HA) in postmenopausal women with vaginal atrophy (VA).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Study 1: Ten subjects received HA and O\n                      <jats:sub>2<\/jats:sub>\n                      at a concentration of 21% (sham group) and ten at 95% (treatment group). All subjects completed five sessions of VNOD. Evaluations and questionnaires were completed at baseline, before each session and at one-month follow-up: Visual Analogue Scale, Vaginal Health Index (VHI), Vaginal Maturation Value (VMV), Menopause Quality Of Life (MeNQoL), Female sexual function index (FSFI) and Female sexual distress scale (FSDS). Study 2: 52 postmenopausal women with VA completed the same protocol of study 1 with HC O\n                      <jats:sub>2<\/jats:sub>\n                      and HA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Treatment was well-tolerated. In study 1, in the treatment group we recorded significant improvements in VHI score (\n                      <jats:italic>p<\/jats:italic>\n                      -value 0.001), VMV (\n                      <jats:italic>p<\/jats:italic>\n                      -value 0.005) and in the psychosocial, physical and sexual domains of the MeNQoL compared to sham group. In study 2, all women experienced a significant improvement in VHI (\n                      <jats:italic>p<\/jats:italic>\n                      -value &lt;0.001), FSFI total score (\n                      <jats:italic>p<\/jats:italic>\n                      -value 0.007), desire (\n                      <jats:italic>p<\/jats:italic>\n                      -value 0.004), lubrication (\n                      <jats:italic>p<\/jats:italic>\n                      -value 0.006), satisfaction (\n                      <jats:italic>p<\/jats:italic>\n                      -value 0.042), pain (\n                      <jats:italic>p<\/jats:italic>\n                      -value 0.001) domains, FSDS score (\n                      <jats:italic>p<\/jats:italic>\n                      -value 0.003) and MeNQoL sexual domain (\n                      <jats:italic>p<\/jats:italic>\n                      -value &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The preliminary results of this study suggest that VNOD is a safe and effective treatment for VA in postmenopausal women, and improves sexual function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20533691241307804","type":"journal-article","created":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T22:19:07Z","timestamp":1734301147000},"page":"9-21","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Topical high concentration oxygen with hyaluronic acid: A safe and effective treatment for vaginal atrophy and sexual function improvement"],"prefix":"10.1080","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6283-6530","authenticated-orcid":false,"given":"Alessandra","family":"Lami","sequence":"first","affiliation":[{"name":"Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy"},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andra Catalina","family":"Manta","sequence":"additional","affiliation":[{"name":"Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy"},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Amati","sequence":"additional","affiliation":[{"name":"Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy"},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Alvisi","sequence":"additional","affiliation":[{"name":"Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy"},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Baldassarre","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Carli","sequence":"additional","affiliation":[{"name":"Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy"},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum 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