{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:02:04Z","timestamp":1791172924018,"version":"4.1.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["JRSM Open"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p> To describe the trends in mortality and the spectrum of disease in HIV-infected and -uninfected inpatients in a population in Yaound\u00e9. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p> A retrospective study. <\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p> Internal Medicine Unit, University Hospital Centre, Yaound\u00e9, Cameroon. <\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p> All deaths registered between January 2000 and May 2007 in the unit. <\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcomes measures<\/jats:title><jats:p> Sociodemographic characteristics, clinical features and results of all investigations done, cause of death. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> During the study period, 362 deaths were registered, consisting of 281 (77.6%) in HIV-infected patients, 54.4% of which were women. HIV-infected patients were younger (mean age: 40.2 (SD: 11.6) vs. 55.5 (SD: 18.3) years, p\u2009&lt;\u20090.001) and economically active (60.3% vs. 24.4%, p\u2009&lt;\u20090.001). Most HIV-infected patients (77.6%) were classified as WHO stage IV, with the rest being WHO stage III. Most HIV-infected patients (87.8%) had evidence of profound immunosuppression (CD4\u2009&lt;\u2009200 cells\/mm<jats:sup>3<\/jats:sup>). The mortality trend appeared to be declining with appropriate interventions. The most frequent causes of death in HIV-infected patients were pleural\/pulmonary tuberculosis (34.2%), undefined meningoencephalitis (20.3%), other pneumonias (18.2%), toxoplasmosis (16.4%), cryptococcal meningitis (14.2%) and Kaposi sarcoma (15.7%). HIV-uninfected patients died mostly as a result of chronic diseases including liver diseases (17.3%), kidney failure (13.6%), congestive heart failure (11.1%) and stroke (9.9%). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> There was a declining mortality due to HIV with appropriate interventions such as subsidised tests for HIV-infected patients, increased availability of HAART and other medications for prevention and treatment of opportunistic infections. The spectrum of HIV disease was wide and preventable. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2054270416654859","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T01:56:41Z","timestamp":1472781401000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Patterns and trends in mortality among HIV-infected and HIV-uninfected patients in a major Internal Medicine Unit in Yaound\u00e9, Cameroon: a retrospective cohort study"],"prefix":"10.1177","volume":"7","author":[{"given":"Josephine","family":"Mbuagbaw","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, University of Buea, PO Box 63, Buea, Cameroon"},{"name":"Internal Medicine Unit, Buea Regional Hospital, PO Box 32, Buea, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmadou M","family":"Jingi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 1, PO Box 1364, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Jacques N","family":"Noubiap","sequence":"additional","affiliation":[{"name":"Department of Medicine, Groote Schuur Hospital and University of Cape Town, 7925 Cape Town, South Africa"},{"name":"Medical Diagnostic Center, PO Box 6230, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud D","family":"Kaze","sequence":"additional","affiliation":[{"name":"Harvard TH Chan School of Public Health, Harvard University, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jobert Richie N","family":"Nansseu","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 1, PO Box 1364, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Joel R","family":"Bigna","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Pasteur Center of Cameroon, PO Box 1274, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edvine","family":"Wawo Yonta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 1, PO Box 1364, Yaound\u00e9, Cameroon"},{"name":"Internal Medicine Unit, Yaound\u00e9 University Hospital Centre, PO Box 4806, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Ngu Blackett","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 1, PO Box 1364, Yaound\u00e9, Cameroon"},{"name":"Internal Medicine Unit, Yaound\u00e9 University Hospital Centre, PO Box 4806, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,9,1]]},"reference":[{"key":"bibr1-2054270416654859","unstructured":"UNAIDS. 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