{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:40:58Z","timestamp":1753882858682,"version":"3.41.2"},"reference-count":9,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["JRSM Open"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p> Lesson <\/jats:p><jats:p> Advanced and metastatic prostate cancer is often managed with hormonal blockage. Luteinising hormone-releasing hormone antagonists achieve rapid testosterone suppression and are used for the treatment of advanced or metastatic prostate cancer. Degarelix is a luteinising hormone-releasing hormone antagonist and is given as a loading dose, followed by a monthly maintenance dose. We report a case where a patient was inadvertently given a second loading dose of Degarelix that resulted in acute psychosis in the form of panic attacks, delusions, suicidal thoughts, insomnia and some visual hallucinations, which are not reported as side-effects of Degarelix. <\/jats:p>","DOI":"10.1177\/2054270420983105","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T09:38:15Z","timestamp":1613727495000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Mistaken administration of a repeat loading dose of Degarelix leading to acute psychosis"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1617-2179","authenticated-orcid":false,"given":"Musaab","family":"Hamdoon","sequence":"first","affiliation":[{"name":"Department of Urology, Darent Valley Hospital, Dartford DA2 8DA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Satchi","sequence":"additional","affiliation":[{"name":"Department of Urology, Darent Valley Hospital, Dartford DA2 8DA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fay","family":"Fawke","sequence":"additional","affiliation":[{"name":"Department of Urology, Darent Valley Hospital, Dartford DA2 8DA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev","family":"Madaan","sequence":"additional","affiliation":[{"name":"Department of Urology, Darent Valley Hospital, Dartford DA2 8DA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"key":"bibr1-2054270420983105","first-page":"465","volume":"166","author":"Shahinian VB","year":"2006","journal-title":"Arch Intern Med"},{"key":"bibr2-2054270420983105","doi-asserted-by":"crossref","unstructured":"Heidenreich A, Pfister D, Ohlmann C and Engelmann U. Androgen deprivation for advanced prostate cancer. Urol\u2009-\u2009Ausgabe A 2008; 47: 270\u2013283.","DOI":"10.1007\/s00120-008-1636-2"},{"key":"bibr3-2054270420983105","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S32426"},{"key":"bibr4-2054270420983105","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.122x"},{"key":"bibr5-2054270420983105","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S8841"},{"key":"bibr6-2054270420983105","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.06598.x"},{"key":"bibr7-2054270420983105","unstructured":"Wharf C and Kingdom U. Assessment report: Firmagon, procedure no. EMEA\/H\/C\/000986. 2011;44. 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