{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:39:54Z","timestamp":1793381994786,"version":"4.5.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["JRSM Open"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p> Acute liver failure is a life-threatening condition commonly caused by drug-induced hepatotoxicity or viral hepatitides. However, there are a number of rarer causes such as haemophagocytic lymphohistiocytosis. Haemophagocytic lymphohistiocytosis is a syndrome of uncontrolled immune cell activation, triggered by infection or malignancy, which carries a high mortality. Whilst mild to moderate liver injury is commonly seen with haemophagocytic lymphohistiocytosis, acute liver failure has rarely been reported in adults. We present a case of a 74-year-old man with acute liver failure secondary to haemophagocytic lymphohistiocytosis triggered by undiagnosed large B-cell lymphoma. Initially treated for biliary sepsis, there was a delay in the diagnosis of haemophagocytic lymphohistiocytosis and despite initiating chemotherapy, he died soon after. This case highlights the importance of considering haemophagocytic lymphohistiocytosis as a rare cause of acute liver failure, as given the life-threatening potential of haemophagocytic lymphohistiocytosis, a prompt diagnosis may allow early initiation of chemotherapy for any chance of survival. <\/jats:p>","DOI":"10.1177\/2054270420983623","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T16:09:30Z","timestamp":1614701370000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A rare cause of acute liver failure due to haemophagocytic lymphohistiocytosis secondary to diffuse large B-cell lymphoma"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6757-9876","authenticated-orcid":false,"given":"Andrew","family":"Coppola","sequence":"first","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London Faculty of Medicine, London SW7 2BU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia","family":"Chey","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Surrey and Sussex Healthcare NHS Trust, Surrey RH1 5RH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"O\u2019Donovan","sequence":"additional","affiliation":[{"name":"Department of Haematology, Surrey and Sussex Healthcare NHS Trust, Surrey RH1 5RH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monira","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Surrey and Sussex Healthcare NHS Trust, Surrey RH1 5RH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"bibr1-2054270420983623","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.016"},{"key":"bibr2-2054270420983623","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2018-101105"},{"key":"bibr3-2054270420983623","doi-asserted-by":"publisher","DOI":"10.1080\/15513819609168681"},{"key":"bibr4-2054270420983623","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000022"},{"key":"bibr5-2054270420983623","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005431"},{"key":"bibr6-2054270420983623","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61048-X"},{"key":"bibr7-2054270420983623","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303632"},{"key":"bibr8-2054270420983623","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26217"},{"key":"bibr9-2054270420983623","doi-asserted-by":"publisher","DOI":"10.14309\/crj.2017.68"},{"key":"bibr10-2054270420983623","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S46255"},{"key":"bibr11-2054270420983623","doi-asserted-by":"publisher","DOI":"10.1002\/art.11368"},{"key":"bibr12-2054270420983623","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.551153"},{"key":"bibr13-2054270420983623","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30826"},{"key":"bibr14-2054270420983623","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181dbbb17"},{"key":"bibr15-2054270420983623","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1992.tb00590.x"},{"key":"bibr16-2054270420983623","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03632.x"},{"key":"bibr17-2054270420983623","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2015-209328"},{"key":"bibr18-2054270420983623","doi-asserted-by":"publisher","DOI":"10.4081\/hr.2010.e5"},{"key":"bibr19-2054270420983623","doi-asserted-by":"publisher","DOI":"10.1159\/000080477"},{"key":"bibr20-2054270420983623","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23911"},{"key":"bibr21-2054270420983623","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"bibr22-2054270420983623","doi-asserted-by":"crossref","unstructured":"Bergsten E, Horne AC, Arico M, Astigarraga I, Egeler RM, Filipovich AH, et al. 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