{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T03:08:19Z","timestamp":1793934499830,"version":"4.8.0"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Kidney Health Dis"],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale:<\/jats:title>\n                    <jats:p>Kidney transplantation has become standard of care for carefully selected patients living with human immunodeficiency virus (HIV) and end-stage renal disease (ESRD) in the highly active antiretroviral therapy (HAART) era. American and European prospective cohort studies have reported similar patient and graft survival compared with HIV-negative kidney transplant recipients. Despite an increased rate of acute rejection, partially due to drug interactions, HIV immunovirologic parameter generally remains under control during immunosuppression. A few cases of kidney transplantation between HIV-infected patients were done in South Africa and showed favorable results. No cases of kidney transplantation from an HIV-positive donor in Canada have previously been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presenting concerns of the patient:<\/jats:title>\n                    <jats:p>A 60-year-old Canadian man with HIV infection presented in 2007 with symptoms compatible with acute renal failure secondary to IgA nephropathy. Chronic kidney disease resulted after the acute episode.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diagnoses:<\/jats:title>\n                    <jats:p>Hemodialysis was started in 2012. The patient was referred for a kidney transplantation evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions:<\/jats:title>\n                    <jats:p>The patient underwent kidney transplantation from an HIV-positive donor in January 2016. The recipient\u2019s antiretroviral regimen consisted of abacavir, lamivudine, and dolutegravir. No drug interactions have been reported between these antiretrovirals and the maintenance immunosuppressive regimen used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes:<\/jats:title>\n                    <jats:p>The outcome at 7 months post transplantation was excellent, with good graft function and adequate control of HIV replication, in the absence of opportunistic infections at a time when immunosuppression is at its highest intensity. No acute rejection was reported. An episode of bacteremic graft pyelonephritis due to Enterococcus faecalis was successfully treated after transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Novel finding:<\/jats:title>\n                    <jats:p>With careful selection of patient, kidney transplantation between HIV-infected patients is a viable option. The use of antiretroviral drugs free of interactions simplified the dosing and management of the immunosuppressive drugs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2054358117695792","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T04:29:20Z","timestamp":1488515360000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["First Canadian Case Report of Kidney Transplantation From an HIV-Positive Donor to an HIV-Positive Recipient"],"prefix":"10.1177","volume":"4","author":[{"given":"Georges","family":"Ambaraghassi","sequence":"first","affiliation":[{"name":"D\u00e9partement de Microbiologie m\u00e9dicale et Infectiologie, H\u00f4pital Maisonneuve-Rosemont, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lo\u00efse","family":"Cardinal","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie, H\u00f4pital Notre-Dame, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Corsilli","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Soins intensifs, H\u00f4pital Saint-Luc, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Fortin","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie m\u00e9dicale et Infectiologie, H\u00f4pital Notre-Dame, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Chantal","family":"Fortin","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie, H\u00f4pital Notre-Dame, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Martel-Laferri\u00e8re","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie m\u00e9dicale et Infectiologie, H\u00f4pital Saint-Luc, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Malaise","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Chirurgie, H\u00f4pital Notre-Dame, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel R.","family":"P\u00e2quet","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie, H\u00f4pital Notre-Dame, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Rouleau","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie m\u00e9dicale et Infectiologie, H\u00f4pital Notre-Dame, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,3,2]]},"reference":[{"key":"bibr1-2054358117695792","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001197"},{"key":"bibr2-2054358117695792","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03258.x"},{"key":"bibr3-2054358117695792","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.02061.x"},{"key":"bibr4-2054358117695792","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.8900"},{"key":"bibr5-2054358117695792","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02637.x"},{"key":"bibr6-2054358117695792","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318221fbda"},{"key":"bibr7-2054358117695792","unstructured":"Kidney Foundation of Canada. Facing the facts. http:\/\/www.kidney.ca\/document.doc?id=1376. Published 2012. Accessed June 23, 2016."},{"key":"bibr8-2054358117695792","unstructured":"S.330: HIV Organ Policy Equity Act. https:\/\/www.govtrack.us\/congress\/bills\/113\/s330\/text. Published 2013. 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