{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:58:37Z","timestamp":1781204317951,"version":"3.54.1"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["App1030973"],"award-info":[{"award-number":["App1030973"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Kidney Health Dis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>There are limited studies on the effects of statins on outcomes in the moderate chronic kidney disease (CKD) population and their trajectory to end-stage kidney disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To examine the long-term effects of lipid-lowering therapy on all-cause mortality, cardiovascular morbidity, CKD progression, and socioeconomic well-being in Australian, New Zealand, and Malaysian SHARP (Study of Heart and Renal Protection) trial participants\u2014a randomized controlled trial of a combination of simvastatin and ezetimibe, compared with placebo, for the reduction of cardiovascular events in moderate to severe CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Protocol for an extended prospective observational follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Australian, New Zealand, and Malaysian participating centers in patients with advanced CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients:<\/jats:title>\n                    <jats:p>All SHARP trial participants alive at the final study visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements:<\/jats:title>\n                    <jats:p>Primary outcomes were measured by participant self-report and verified by hospital administrative data. In addition, secondary outcomes were measured using a validated study questionnaire of health-related quality of life, a 56-item economic survey.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Participants were followed up with alternating face-to-face visits and telephone calls on a 6-monthly basis until 5 years following their final SHARP Study visit. In addition, there were 6-monthly follow-up telephone calls in between these visits. Data linkage to health registries in Australia, New Zealand, and Malaysia was also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The SHARP-Extended Review (SHARP-ER) cohort comprised 1136 SHARP participants with a median of 4.6 years of follow-up. Compared with all SHARP participants who originally participated in the Australian, New Zealand, and Malaysian regions, the SHARP-ER participants were younger (57.2 [48.3-66.4] vs 60.5 [50.3-70.7] years) with a lower proportion of men (61.5% vs 62.8%). There were a lower proportion of participants with hypertension (83.7% vs 85.0%) and diabetes (20.0% vs 23.5%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations:<\/jats:title>\n                    <jats:p>As a long-term follow-up study, the surviving cohort of SHARP-ER is a selected group of the original study participants, which may limit the generalizability of the findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The SHARP-ER study will contribute important evidence on the long-term outcomes of cholesterol-lowering therapy in patients with advanced CKD with a total of 10 years of follow-up. Novel analyses of the socioeconomic impact of CKD over time will guide resource allocation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration:<\/jats:title>\n                    <jats:p>The SHARP trial was registered at ClinicalTrials.gov NCT00125593 and ISRCTN 54137607.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2054358119879896","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T02:48:10Z","timestamp":1571107690000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Protocol for the Study of Heart and Renal Protection-Extended Review: Additional 5-Year Follow-up of the Australian, New Zealand, and Malaysian SHARP Cohort"],"prefix":"10.1177","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7409-2938","authenticated-orcid":false,"given":"Louisa","family":"Sukkar","sequence":"first","affiliation":[{"name":"The George Institute for Global Health, Newtown, Australia"},{"name":"Faculty of Medicine and Health, The University of Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Talbot","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Newtown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jun","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Newtown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Dempsey","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Newtown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Walker","sequence":"additional","affiliation":[{"name":"Dunedin School of Medicine, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai","family":"Hooi","sequence":"additional","affiliation":[{"name":"Hospital Sultanah Aminah, Johor Bahru, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Cass","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research, Casuarina, NT, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meg","family":"Jardine","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Newtown, Australia"},{"name":"Faculty of Medicine and Health, The University of Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9187-6187","authenticated-orcid":false,"given":"Martin","family":"Gallagher","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Newtown, Australia"},{"name":"Faculty of Medicine and Health, The University of Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,10,14]]},"reference":[{"key":"bibr1-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60595-4"},{"key":"bibr2-2054358119879896","volume-title":"The Economic Impact of End-stage Kidney Disease in Australia: Projections to 2020","author":"Cass AC","year":"2010"},{"key":"bibr3-2054358119879896","volume-title":"ANZDATA Report 2013","author":"Australia and New Zealand Dialysis and Transplant Registry","year":"2013"},{"key":"bibr4-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005101085"},{"key":"bibr5-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.531"},{"key":"bibr6-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043545"},{"key":"bibr7-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810177"},{"key":"bibr8-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13638-0"},{"key":"bibr9-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60739-3"},{"key":"bibr10-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61125-2"},{"key":"bibr11-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08351-4"},{"key":"bibr12-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072642"},{"key":"bibr13-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)00910-3"},{"key":"bibr14-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019014"},{"key":"bibr15-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01105.x"},{"key":"bibr16-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2015.12.033"},{"key":"bibr17-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.08.012"},{"key":"bibr18-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(90)90421-9"},{"key":"bibr19-2054358119879896","doi-asserted-by":"crossref","unstructured":"Grootaert C, Narayan D, Jones VN, Woolcock M. Measuring Social Capital: An Integrated Questionnaire (World bank working paper). Washington, DC: The World Bank; 2004.","DOI":"10.1596\/0-8213-5661-5"},{"key":"bibr20-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2005.10.020"},{"key":"bibr21-2054358119879896","unstructured":"Survey of Income and Program Participation (SIPP)\n                      . Washington, DC: DUCB; 2010. http:\/\/www.census.gov\/sipp\/. Accessed September 20, 2016."},{"key":"bibr22-2054358119879896","unstructured":"Australian Institute of Health and Welfare. National death index 2016. https:\/\/www.aihw.gov.au\/about-our-data\/our-data-collections\/national-death-index. Accessed January 28, 2019."},{"key":"bibr23-2054358119879896","unstructured":"Australian and New Zealand dialysis and transplant registry 2016. http:\/\/www.anzdata.org.au. Accessed January 28, 2019."},{"key":"bibr24-2054358119879896","unstructured":"Medicare benefits schedule 2017. http:\/\/www.mbsonline.gov.au\/internet\/mbsonline\/publishing.nsf\/Content\/Home. Accessed January 28, 2019."},{"key":"bibr25-2054358119879896","unstructured":"Pharmaceutical benefits scheme 2016. http:\/\/www.health.gov.au\/pbs. Accessed January 28, 2019."},{"key":"bibr26-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-4991.1997.tb00222.x"},{"key":"bibr27-2054358119879896","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-9-182"},{"key":"bibr28-2054358119879896","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.15.158303"}],"container-title":["Canadian Journal of Kidney Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2054358119879896","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2054358119879896","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2054358119879896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:23:11Z","timestamp":1777389791000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2054358119879896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":28,"alternative-id":["10.1177\/2054358119879896"],"URL":"https:\/\/doi.org\/10.1177\/2054358119879896","relation":{},"ISSN":["2054-3581","2054-3581"],"issn-type":[{"value":"2054-3581","type":"print"},{"value":"2054-3581","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"article-number":"2054358119879896"}}