{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:16:30Z","timestamp":1790662590696,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Kidney Foundation of Thailand"},{"DOI":"10.13039\/501100010724","name":"health systems research institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010724","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Kidney Health Dis"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>There is no consensus on intravenous (IV) iron supplement dose, schedule, and serum ferritin target in functional iron deficiency anemia to maintain optimum target levels of iron stores by several guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To examine the effect of IV iron supplementation to different targets of serum ferritin on erythropoietin dose and inflammatory markers in chronic hemodialysis (HD) patients with functional iron deficiency anemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A multicenter, randomized, open-label study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>In a developing country, Thailand.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients:<\/jats:title>\n                    <jats:p>Chronic HD patients with functional iron deficiency anemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements:<\/jats:title>\n                    <jats:p>Erythropoietin resistance index, high-sensitivity C-reactive protein, and fibroblast growth factor 23.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Two hundred adult chronic HD patients with transferrin saturation less than 30% and serum ferritin of 200 to 400 ng\/mL were randomized 1:1 to maintain serum ferritin 200 to 400 ng\/mL (low-serum ferritin group, N = 100) or 600 to 700 ng\/mL (high-serum ferritin group, N = 100). During a 6-week titration period, participants randomized to the high-serum ferritin group initially received 600 mg IV iron (100 mg every week), while the participants in the low-serum ferritin group did not receive IV iron. During the 6-month follow-up period, the dose of IV iron was adjusted by protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mean dose of IV iron was 108.3 \u00b1 28.2 mg\/month in the low-serum ferritin group and 192.3 \u00b1 36.2 mg\/month in the high-serum ferritin group. The mean serum ferritin was 367.0 \u00b1 224.9 ng\/mL in the low ferritin group and 619.6 \u00b1 265.2 ng\/mL in the high ferritin group. The erythropoietin resistance index was significantly decreased in the high-serum ferritin group compared to the low-serum ferritin group after receiving IV iron in the 6-week titration period (mean difference: \u2212113.43 \u00b1 189.14 vs 41.08 \u00b1 207.38 unit\/week\/g\/dL; P &lt; .001) and 3-month follow-up period (mean differences: \u221288.88 \u00b1 234.43 vs \u221210.48 \u00b1 217.75 unit\/week\/g\/dL; P = .02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations:<\/jats:title>\n                    <jats:p>Short follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Maintaining a serum ferritin level of 600 to 700 ng\/mL by IV iron administration of approximately 200 mg per month as a maintenance protocol can decrease erythropoietin dose requirements in chronic HD patients with functional iron deficiency anemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trials registration:<\/jats:title>\n                    <jats:p>The study was registered with the Thai Clinical Trials Registry TCTR20180903003.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2054358120933397","type":"journal-article","created":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T02:15:26Z","timestamp":1592619326000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of Maintenance Intravenous Iron Treatment on Erythropoietin Dose in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial"],"prefix":"10.1177","volume":"7","author":[{"given":"Paweena","family":"Susantitaphong","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand"},{"name":"Research Unit for Metabolic Bone Disease in CKD Patients, Faculty of Medicine, Chulalongkorn University, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monchai","family":"Siribumrungwong","sequence":"additional","affiliation":[{"name":"Nephrology Unit, Department of Medicine, Lerdsin Hospital, College of Medicine, Rangsit University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-8893","authenticated-orcid":false,"given":"Kullaya","family":"Takkavatakarn","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamonrat","family":"Chongthanakorn","sequence":"additional","affiliation":[{"name":"Nephrology Unit, Department of Medicine, Charoenkrung Pracharak Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songkiat","family":"Lieusuwan","sequence":"additional","affiliation":[{"name":"Boonyavej Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pisut","family":"Katavetin","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khajohn","family":"Tiranathanagul","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sookruetai","family":"Lekhyananda","sequence":"additional","affiliation":[{"name":"The Kidney Foundation of Thailand, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kriang","family":"Tungsanga","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supat","family":"Vanichakarn","sequence":"additional","affiliation":[{"name":"The Kidney Foundation of Thailand, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somchai","family":"Eiam-Ong","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kearkiat","family":"Praditpornsilpa","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Chulalongkorn University, King Chulalongkorn Memorial 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