{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:44:15Z","timestamp":1780051455431,"version":"3.53.1"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Kidney Health Dis"],"published-print":{"date-parts":[[2020,1]]},"abstract":"\n Background:<\/jats:title>\n Clinical research requires that diagnostic codes captured from routinely collected health administrative data accurately identify individuals with a disease.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n In this study, we validated the International Classification of Disease 10th Revision (ICD-10) definition for kidney transplant rejection (T86.100) and for kidney transplant failure (T86.101).<\/jats:p>\n <\/jats:sec>\n \n Design:<\/jats:title>\n Retrospective cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting:<\/jats:title>\n A large, regional transplantation center in Ontario, Canada.<\/jats:p>\n <\/jats:sec>\n \n Patients:<\/jats:title>\n All adult kidney transplant recipients from 2002 to 2018.<\/jats:p>\n <\/jats:sec>\n \n Measurements:<\/jats:title>\n Chart review was undertaken to identify the first occurrence of biopsy-confirmed rejection and graft loss for all participants. For each observation, we determined the first date a single ICD-10 code T86.100 or T86.101 was recorded as a hospital encounter discharge diagnosis.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Using chart review as the gold standard, we determined the sensitivity, specificity, and positive predictive value (PPV) for the ICD-10 codes T86.100 and T86.101.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Our study population comprised of 1,258 kidney transplant recipients. The prevalence of rejection and death-censored graft loss were 15.6 and 9.1%, respectively. For the ICD-10 rejection code (T86.100), sensitivity was 72.9% (95% confidence interval [CI], 66.6-79.2), specificity 97.5% (96.5-98.4), and PPV 83.8% (78.3-89.4). For the ICD-10 graft loss code (T86.101), sensitivity was 21.2% (95% CI, 13.2-29.3), specificity 86.3% (84.3-88.3), and PPV 11.7% (7.0-16.4).<\/jats:p>\n <\/jats:sec>\n \n Limitations:<\/jats:title>\n Single-center study which may limit generalizability of our findings.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n A single ICD-10 code for kidney transplant rejection (T86.100) was present in 84% of true kidney transplant rejections and is an accurate way of identifying kidney transplant recipients with rejection using administrative health data. The ICD-10 code for graft failure (T86.101) performed poorly and should not be used for administrative health research.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/2054358120977390","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T04:25:00Z","timestamp":1608092700000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Validation of the International Classification of Disease 10th Revision Codes for Kidney Transplant Rejection and Failure"],"prefix":"10.1177","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6954-2030","authenticated-orcid":false,"given":"David","family":"Massicotte-Azarniouch","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish M.","family":"Sood","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Kidney Research Center, Department of Medicine, University of Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean A.","family":"Fergusson","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program, Ottawa Hospital Research Institute, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg A.","family":"Knoll","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Kidney Research Center, Department of Medicine, University of Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,12,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.01.001."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.08.002."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181f98300."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181661695."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.09.003."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41073-016-0014-7."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40697-015-0054-9."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.07.043."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000692."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.2181."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14625."},{"key":"e_1_3_2_13_2","unstructured":"Interpretation of diagnostic data: 5. How to do it with simple maths. Can Med Assoc J. 1983;129(9):947-954. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/6671182. Accessed January 15 2020."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/23.3.205."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdr054."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181e81b16."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002141."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-015-0028-2."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14557."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19970515)16:9<981::AID-SIM510>3.0.CO;2-N."}],"container-title":["Canadian Journal of Kidney Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2054358120977390","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2054358120977390","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2054358120977390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:23:42Z","timestamp":1777389822000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2054358120977390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":19,"alternative-id":["10.1177\/2054358120977390"],"URL":"https:\/\/doi.org\/10.1177\/2054358120977390","relation":{},"ISSN":["2054-3581","2054-3581"],"issn-type":[{"value":"2054-3581","type":"print"},{"value":"2054-3581","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"2054358120977390"}}