{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:58:59Z","timestamp":1787626739242,"version":"build-2736575974"},"reference-count":47,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"canadian institutes of health research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004324","name":"astellas pharma us","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Kidney Health Dis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Although living kidney donation is safe, some donors experience perioperative complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study explored how perioperative complications affected donor-reported health-related quality of life, depression, and anxiety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This research was a conducted as a prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Twelve transplant centers across Canada.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients:<\/jats:title>\n                    <jats:p>A total of 912 living kidney donors were included in this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements:<\/jats:title>\n                    <jats:p>Short Form 36 health survey, Beck Depression Inventory and Beck Anxiety Inventory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Living kidney donors were prospectively enrolled predonation between 2009 to 2014. Donor perioperative complications were graded using the Clavien-Dindo classification system. Mental and physical health-related quality of life was assessed with the 3 measurements; measurements were taken predonation and at 3- and 12-months postdonation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Seventy-four donors (8%) experienced a perioperative complication; most were minor (n = 67 [91%]), and all minor complications resolved before hospital discharge. The presence (versus absence) of a perioperative complication was associated with lower mental health-related quality of life and higher depression symptoms 3-month postdonation; neither of these differences persisted at 12-month. Perioperative complications were not associated with any changes in physical health-related quality of life or anxiety 3-month postdonation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations:<\/jats:title>\n                    <jats:p>Minor complications may have been missed and information on complications postdischarge were not collected. No minimal clinically significant change has been defined for kidney donors across the 3 measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These findings highlight a potential opportunity to better support the psychosocial needs of donors who experience perioperative complications in the months following donation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>NCT00319579 and NCT00936078.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20543581211037429","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T06:17:12Z","timestamp":1628662632000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Impact of Perioperative Complications on Living Kidney Donor Health-Related Quality of Life and Mental Health: Results From a Prospective Cohort Study"],"prefix":"10.1177","volume":"8","author":[{"given":"Carlos","family":"Garcia-Ochoa","sequence":"first","affiliation":[{"name":"London Health Sciences Centre, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liane S.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Surgery, McGill University Health Centre, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Nguan","sequence":"additional","affiliation":[{"name":"The University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Monroy-Caudros","sequence":"additional","affiliation":[{"name":"Foothills Medical Center, University of Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer B.","family":"Arnold","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2403-2392","authenticated-orcid":false,"given":"Lianne","family":"Barnieh","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Boudville","sequence":"additional","affiliation":[{"name":"Medical School, Department of Renal Medicine, Sir Charles Gairdner Hospital, The University of Western Australia, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meaghan S.","family":"Cuerden","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Dipchand","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Dalhousie University, Halifax, NS, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Gill","sequence":"additional","affiliation":[{"name":"The University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Karpinski","sequence":"additional","affiliation":[{"name":"University of Manitoba, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Klarenbach","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University of Alberta, Edmonton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Knoll","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charmaine E.","family":"Lok","sequence":"additional","affiliation":[{"name":"University of Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Miller","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Transplantation, St. Joseph\u2019s Healthcare Hamilton, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. V. Ramesh","family":"Prasad","sequence":"additional","affiliation":[{"name":"St. Michael\u2019s Hospital, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7784-2028","authenticated-orcid":false,"given":"Jessica M.","family":"Sontrop","sequence":"additional","affiliation":[{"name":"Department of Epidemiology & Biostatistics, Western University, London, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leroy","family":"Storsley","sequence":"additional","affiliation":[{"name":"University of Manitoba, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3398-3114","authenticated-orcid":false,"given":"Amit X.","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Epidemiology & Biostatistics, Western University, London, ON, Canada"},{"name":"Department of Medicine, Western University, London, ON, Canada"},{"name":"Institute for Clinical Evaluative Sciences, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"bibr1-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.237"},{"key":"bibr2-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13687"},{"key":"bibr3-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92683-7"},{"key":"bibr4-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001252"},{"key":"bibr5-20543581211037429","doi-asserted-by":"publisher","DOI":"10.7326\/M17-1235"},{"key":"bibr6-20543581211037429","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11220918"},{"key":"bibr7-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1177\/2054358119857718"},{"key":"bibr8-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-014-0194-0"},{"key":"bibr9-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2004.05.280"},{"key":"bibr10-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.07.045"},{"key":"bibr11-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-007224"},{"key":"bibr12-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2009.05.007"},{"key":"bibr13-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199903150-00013"},{"key":"bibr14-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy307"},{"key":"bibr15-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13453."},{"key":"bibr16-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2012.01687.x"},{"key":"bibr17-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12434."},{"key":"bibr18-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01567.x"},{"key":"bibr19-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12974"},{"key":"bibr20-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2007.08.012"},{"key":"bibr21-20543581211037429","first-page":"S12","volume":"2012","author":"Matheson FI","journal-title":"Can J Public Heal Can Sante\u2019e Publique"},{"key":"bibr22-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b13ca2"},{"key":"bibr23-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-008-9584-y"},{"key":"bibr24-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"bibr25-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-015-3003-y"},{"key":"bibr26-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"bibr27-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.56.6.893"},{"key":"bibr28-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"bibr29-20543581211037429","first-page":"AS264","volume":"33","author":"Ware JE","year":"1995","journal-title":"Med Care"},{"key":"bibr30-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1016\/0887-6185(92)90026-4"},{"key":"bibr31-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2011.09.008"},{"issue":"3","key":"bibr32-20543581211037429","first-page":"265","volume":"163","author":"Hopman WM","year":"2000","journal-title":"CMAJ"},{"key":"bibr33-20543581211037429","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002089"},{"key":"bibr34-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199401000-00004"},{"key":"bibr35-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-010-9740-3"},{"key":"bibr36-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1080\/10629360600810434"},{"key":"bibr37-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2001.4"},{"key":"bibr38-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-008-9426-2"},{"key":"bibr39-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-008-9404-8"},{"key":"bibr40-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-008-9018-y"},{"key":"bibr41-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1177\/096228029900800102"},{"key":"bibr42-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2017.10.019"},{"key":"bibr43-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.05.022"},{"key":"bibr44-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12760."},{"key":"bibr45-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318253f1bc"},{"key":"bibr46-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2019.01.154"},{"key":"bibr47-20543581211037429","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.4064"}],"container-title":["Canadian Journal of Kidney Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20543581211037429","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20543581211037429","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20543581211037429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:23:56Z","timestamp":1777389836000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20543581211037429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":47,"alternative-id":["10.1177\/20543581211037429"],"URL":"https:\/\/doi.org\/10.1177\/20543581211037429","relation":{},"ISSN":["2054-3581","2054-3581"],"issn-type":[{"value":"2054-3581","type":"print"},{"value":"2054-3581","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"20543581211037429"}}